The Antimicrobial Activity of Different Extracts from Echinophora platyloba DC.

  • Leili Bazvandi Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Yalda Shokoohinia Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Nastaran Ghiasvand Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Parviz Mohajeri Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Behnam Ashrafi Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Iraj Salimikia* Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
DOI: https://doi.org/10.22087/hmj.v0i0.655
Keywords: Echinophora platyloba DC., Extracts, Antimicrobial

Abstract

Background and Aim: Echinophora platyloba DC (Apiaceae) is a plant endemic to Kurdistan province of Iran. Aerial part of the plant is regarded as the source of natural antimicrobial agent.Materials and Methods: The aerial part of E. platyloba was extracted with hexane, dichloromethane, acetone EtOH and EtOH: H2O respectively. The extracts were individually tested against three gram-negative (Escherichia coli, Shigella flexneri, Acinetobacter baumannii) and two gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) via agar dilution methods.Results: The best inhibitory effect was observed in ethanolic extract, which had a remarkable inhibitory effect on all bacteria especially on S. aureus. The results also indicated that dichloromethane extract showed the weakest inhibitory effect on all types of bacteria. Meanwhile, acetone extract exhibited a relatively mild inhibitory effect.Conclusion: The antimicrobial effects of E. platyloba confirmed its potential for folk use. More comprehensive investigations are recommended concerning the significant antibacterial activity of the ethanol extract of E. platyloba to determine the exact compounds responsible for observed biological activities.

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Issue
VOL 2, NO 4, 2017
Section
Original Article

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