The Antifungal Effect of Thymus Vulgaris on Isolated Candida Albicans from the Surface of Removable Orthodontic Appliances

Farkhondeh Kavianirad, Nima Bahador, Navid Naseri, Tahereh Baherimoghadam *, Roja Safaeian


Background and Aim: Orthodontic appliances can impair the balance of oral microflora and increase the load of certain microorganisms in the oral cavity. Chlorhexidine (CHX) is the gold-standard antimicrobial agent for plaque control. However, its long-term use is associated with adverse effects. The present study aimed to assess the effect of essential oil of Thymus vulgaris on isolated Candida Albicans from removable orthodontic appliances.

Materials and Methods: In this study Thirty-two dental students were requested to use removable orthodontic appliances for 7 days. Then, the acrylic base of the appliance were checked for isolation of Candida Albicans. Furthermore, effect of Thymus Vulgaris essential oil were evaluated on Candida Albicans using disc diffusion method and Its minimum inhibitory concentration (MIC) was also determined.

Results: The results obtained from this study indicated that the essential oil of Thymus vulgaris was significantly more effective than CHX in elimination of isolated Candida Albicans from the surface of orthodontic appliances (P<0.05), and its MIC was calculated to be 15.6 µL/mL.

Conclusion: The essential oil of Thymus vulgaris has favorable antimicrobial activity against Candida Albicans superior to that of CHX.


Removable Acrylic Orthodontic Appliance; Thymus Vulgaris Essential Oil; Candida albicans; Chlorhexidine Mouthwash

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Lorestan University of Medical Sciences, Khorramabad, Iran.

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