Phytochemical Screening, Antioxidant and Gastro-Protective Activity Studies on the Fruit Peels of Selected Varieties of Banana

Dennis Gogola *

Abstract


Background and Aim: Gastric ulcer is a chronic health condition of the gastrointestinal tract with increasing incidence and prevalence affecting both male and female population globally. There were a variety of drugs used, but are costly and exhibited limited efficacy and causing adverse reactions. Hence, the study aimed to screen the phytochemicals, antioxidant and anti-ulcer activities of ethanolic fruit peel extracts of M. acuminata Colla, M. paradisiaca L., and M. acuminata Colla cv. Señorita.

Materials and Methods: The determination of total phenolics and flavonoids were performed using conventional methods. The free radical scavenging activity of the extracts was evaluated by using the DPPH (1, 1-Diphenyl-2 -picrylhydrazyl). Also, the anti-ulcer activity was examined by using three ulcer models in rats.

Results: The total phenolic contents of the peel extracts ranged from 12.3 to 40.3 mg gallic acid equivalents (GAE)/g dry weight (dw), whereas the flavonoid ranged from 2.5 to 16.6 mg GAE/g dw. The results showed that the peel extracts exhibited free radical scavenging capacity (DPPH) that ranged from 51.52 to 72.00% at the concentration of 100 μg/mL. Also, the peel extracts showed gastroprotective activities against alcohol, drug, and stress-induced ulcers in rats. The maximum percent ulcer inhibition of the peel extracts against ethanol-induced ulcer was 83.33, whereas 100% against both the aspirin and cold restraint stress-induced ulcers.

Conclusion: The obtained results suggest that the fruit peel extracts of M. acuminata Colla, M. paradisiaca L., and M. acuminata Colla cv. Señorita has antioxidant capacity. They also exhibited anti-ulcer activity and contained active compounds that are potentially responsible for its biological and pharmacological properties. As such, the results warrant further exploration of the peel extracts as it is a promising plant material for its potential applications in the nutraceutical and pharmaceutical industries.

Keywords


Gastroprotective, Anti-ulcer, Antioxidant, Phytochemicals, Banana peels

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References


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DOI: https://doi.org/10.22087/herb%20med%20j.v5i2.763

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