Efficacy of Thymol on the Scolices of Hydatid Cyst
Abstract
As one of the major constituents of medicinal plant extracts, thymol has remarkable anti-worm properties. The contents of 5 English databases, including Scopus, PubMed, Web of Science, Embase and Google Scholar in the time span from 2008 to December 2019 were searched. All the relevant studies with English abstracts were searched regardless of the language of their discussions. Words and terms are used as syntax with specific tags from each database. Eleven out of 2146 studies were found eligible for evaluation. The findings indicated that 100% of the studies were about hydatid cysts and thymol. Moreover, 6 in vitro (55%) and 3 in vivo studies (27%), as well as 2 studies both in vitro and in vivo (18%), were carried out. According to these studies, thymol, as one of the major constituents of plant compounds, has a significant role in killing and reducing the parasitic protoscolex in vitro and in vitro. Likewise, thymol could have significant effects on restructuring protoscoleces and ultimately on their mortality. Thymol has an anti-hydatid cyst effect with the least side effects, and could be a good alternative to the treatment and prevention of anti-protoscoleces infections or in other studies against other helminth infections.References
David T, William A, Markell E, Vege S. Medical parasitology. New York: Saunders Elsevier. 2006.
Mohammadi GA, Mobedi I, Ariaiepour M, Pourmohammadi Z, Bidaki MZ. A case report of nasopharyngeal linguatuliasis in Tehran, Iran and characterization of the isolated Linguatula serrata. Iranian Journal of Parasitology. 2008:53-5.
Wang Y, Rogan M, Vuitton D, Wen H, Bartholomot B, Macpherson C, et al. Cystic echinococcosis in semi-nomadic pastoral communities in north-west China. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2001;95(2):153-8.
Prasad J, Bellamy P, Stubbs R. Instillation of scolicidal agents into hepatic hydatid cysts: can it any longer be justified? The New Zealand medical journal. 1991;104(917):336.
Poyrazoğlu E, Gökmen V, Artιk N. Organic acids and phenolic compounds in pomegranates (Punica granatum L.) grown in Turkey. Journal of food composition and analysis. 2002;15(5):567-75.
Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007;21(4):308-23.
Hulin V, Mathot A-G, Mafart P, Dufossé L. Les proprietés anti-microbiennes des huiles essentielles et composés d'arômes. Sciences des aliments. 1998;18(6):563-82.
Hammond J, Fielding D, Bishop S. Prospects for plant anthelmintics in tropical veterinary medicine. Veterinary research communications. 1997;21(3):213-28.
Liolios C, Gortzi O, Lalas S, Tsaknis J, Chinou I. Liposomal incorporation of carvacrol and thymol isolated from the essential oil of Origanum dictamnus L. and in vitro antimicrobial activity. Food chemistry. 2009;112(1):77-83.
Robledo S, Osorio E, Munoz D, Jaramillo LM, Restrepo A, Arango G, et al. In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives. Antimicrobial agents and chemotherapy. 2005;49(4):1652-5.
Hierro I, Valero A, Perez P, Gonzalez P, Cabo M, Montilla M, et al. Action of different monoterpenic compounds against Anisakis simplex sl L3 larvae. Phytomedicine. 2004;11(1):77-82.
Elissondo MC, Pensel PE, Denegri GM. Could thymol have effectiveness on scolices and germinal layer of hydatid cysts? Acta tropica. 2013;125(3):251-7.
Elissondo MC, Albani CM, Gende L, Eguaras M, Denegri G. Efficacy of thymol against Echinococcus granulosus protoscoleces. Parasitology international. 2008;57(2):185-90.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS medicine. 2009;6(7):e1000100.
Pensel PE, Maggiore MA, Gende LB, Eguaras MJ, Denegri M, Elissondo MC. Efficacy of essential oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus. Interdisciplinary perspectives on infectious diseases. 2014;2014.
Mahmoudvand H, Mirbadie SR, Sadooghian S, Harandi MF, Jahanbakhsh S, Saedi Dezaki E. Chemical composition and scolicidal activity of Zataria multiflora Boiss essential oil. Journal of EssEntial oil rEsEarch. 2017;29(1):42-7.
Moazeni M, Larki S, Pirmoradi G, Rahdar M. Scolicidal effect of the aromatic water of Zataria multiflora: an in vitro study. Comparative Clinical Pathology. 2015;24(5):1057-62.
Albani CM, Denegri GM, Elissondo MC. Effect of different terpene-containing essential oils on the proliferation of Echinococcus granulosus larval cells. Interdisciplinary perspectives on infectious diseases. 2014;2014.
Moazeni M, Saharkhiz MJ, Hosseini AA. In vitro lethal effect of ajowan (Trachyspermum ammi L.) essential oil on hydatid cyst protoscoleces. Veterinary parasitology. 2012;187(1-2):203-8.
Yones DA, Taher GA, Ibraheim ZZ. In vitro effects of some herbs used in Egyptian traditional medicine on viability of protoscolices of hydatid cysts. The Korean journal of parasitology. 2011;49(3):255.
Albani CM, Pensel PE, Elissondo N, Gambino G, Elissondo MC. In vivo activity of albendazole in combination with thymol against Echinococcus multilocularis. Veterinary parasitology. 2015;212(3-4):193-9.
Maggiore M, Pensel PE, Denegri G, Elissondo MC. Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis. Parasitology international. 2015;64(5):435-40.
Moazeni M, Larki S, Saharkhiz MJ, Oryan A, Lari MA, Alavi AM. In vivo study of the efficacy of the aromatic water of Zataria multiflora on hydatid cysts. Antimicrobial agents and chemotherapy. 2014;58(10):6003-8.
Ustünsöz B, Akhan O, Kamiloğlu M, Somuncu I, Uğurel M, Cetiner S. Percutaneous treatment of hydatid cysts of the liver: long-term results. AJR American journal of roentgenology. 1999;172(1):91-6.
Altindis M, Arikan Y, Cetinkaya Z, Polat C, Yılmaz S, Akbulut G, et al. Octenidine hydrochloride in hydatid disease. Journal of Investigative Surgery. 2004;17(1):41-4.
Sahin M, Eryilmaz R, Bulbuloglu E. The effect of scolicidal agents on liver and biliary tree (experimental study). Journal of Investigative Surgery. 2004;17(6):323-6.
Pawlowski Z. Echinococcosis in humans: clinical aspects, diagnosis and treatment. WHO/OIE Manual on echinococcosis in humans and animals. 2001.
Prabhakar J, Senthilkumar M, Priya M, Mahalakshmi K, Sehgal P, Sukumaran V. Evaluation of antimicrobial efficacy of herbal alternatives (Triphala and green tea polyphenols), MTAD, and 5% sodium hypochlorite against Enterococcus faecalis biofilm formed on tooth substrate: an in vitro study. Journal of endodontics. 2010;36(1):83-6.
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