Antiviral Properties of Peganum Harmala (Espand) as a Medicinal Plant: A Literature Review
Abstract
Labeled Objective: Peganum Harmala is a traditional multipurpose medicinal plant in Iran, China and other countries of Asia and Africa. This review study intends to identify and report its antiviral properties. To carry out this review article, the articles published by Scopus, PubMed, EMBASE, ScienceDirect, Google Scholar, SID, and Magiran from 2010 to 2020 were searched. The key words included Peganum harmala, viral, and virus. 32 articles were found eligible after screening titles and abstracts. After excluding the articles that met the exclusion criteria, eight studies remained. In these studies, the effects of Peganum harmala on some viruses such as the human immunodeficiency virus, influenza A virus, herpes simplex virus type 2, enterovirus 71, herpes simplex virus type 1, and coxsackie B virus type 3 has been investigated. In all of the studies under review, P. harmala smoke or extract has been introduced as an effective antiviral even compared to other disinfectants. According to these findings, it is recommended to pay attention to the Peganum Harmala in processes of viral infections treatments and environmental viral disinfectionReferences
Ghorbani A. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran:(Part 1): General results. Journal of ethnopharmacology. 2005;102(1):58-68.
Li S, Cheng X, Wang C. A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum. J Ethnopharmacol. 2017;203:127-62.
Khan NA, Raina A, Wagay NA, Tantray YR. Distribution, Status, Pharmacological, and Traditional importance of Peganum harmala. international hournal advance research in science and engineering. 2017;6(8).
Iqbal Z, Javed M, Rafique G, Saleem T. A comparative study of total phenolic contents and antioxidant potential of seeds of Peganum harmala. International Journal of Biosciences | IJB |. 2019;14(3):121-7.
Herraiz T, Guillén H, Arán VJ, Salgado A. Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala. Food and Chemical Toxicology. 2017;1(103):261-9.
Shin HJ, Lee H-S, Lee D-S. The synergistic antibacterial activity of 1-acetyl-beta-carboline and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA). J Microbiol Biotechnol. 2010;20(3):501-5.
Olmedo GM, Cerioni L, González MM, Cabrerizo FM, Rapisarda VA, Volentini SI. Antifungal activity of β-carbolines on Penicillium digitatum and Botrytis cinerea. Food Microbiology. 2017;62:9-14.
Olmedo GM, Cerioni L, González MM, Cabrerizo FM, Volentini SI, Rapisarda VA. UVA Photoactivation of Harmol Enhances Its Antifungal Activity against the Phytopathogens Penicillium digitatum and Botrytis cinerea. Frontiers in Microbiology. 2017 2017-March-07;8(347). English.
Alomar ML, Rasse-Suriani FAO, Ganuza A, Cóceres VM, Cabrerizo FM, Angel SO. In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents. BMC research notes. 2013;6(1):193.
Quintana VM, Piccini LE, Panozzo Zénere JD, Damonte EB, Ponce MA, Castilla V. Antiviral activity of natural and synthetic β-carbolines against dengue virus. Antiviral Research. 2016;134:26-33.
Ishida J, Wang H-K, Oyama M, Cosentino ML, Hu C-Q, Lee K-H. Anti-AIDS Agents. 46. Anti-HIV Activity of Harman, an Anti-HIV Principle from Symplocos setchuensis, and Its Derivatives. Journal of Natural Products. 2001;64(7):958-60.
Wang Y-H, Tang J-G, Wang R-R, Yang L-M, Dong Z-J, Du L, et al. Flazinamide, a novel β-carboline compound with anti-HIV actions. Biochemical and Biophysical Research Communications. 2007;355(4):1091-5.
Nazari Formagio AS, Santos PR, Zanoli K, Ueda-Nakamura T, Düsman Tonin LT, Nakamura CV, et al. Synthesis and antiviral activity of β-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1). European Journal of Medicinal Chemistry. 2009 2009;44(11):4695-701.
Hudson JB, Graham EA, Fong R, Hudson LL, Towers GHN. Further Studies on The Antiviral Activity of Harmine, A Photoactive Β-Carboline Alkaloid. Photochemistry and Photobiology. 1986;44(4):483-7.
Mohammad Taghizadeh Kashani L, Masoudi S, Ahmadian-Attari MM. Antimicrobial and Antioxidant Activities of Some Medicinal Smokes Prescribed in Iranian Traditional Medicine for Catarrh. Int J Enteric Pathog. 2019;7(3):70-4.
Shahverdi AR, Monsef-Esfahani HR, Nickavar B, Bitarafan L, Khodaee S, Khoshakhlagh N. Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Zeitschrift für Naturforschung C. 2005;60(9-10):707-10.
Al-Izzy MY. Antimicrobial effects of aqueous and alcoholic extract of Peganum harmala L. seeds on two types of salivary isolated microorganisms in Al-Ramadi city. Journal of King Abdulaziz University: Medical Sciences. 2010;98(280):1-30.
Shabani Z, Sayadi A. The antimicrobial in vitro effects of different concentrations of some plant extracts including tamarisk, march, acetone and mango kernel. Journal of Applied Pharmaceutical Science. 2014;4(5):75.
jadidi A, Golitaleb M, Sadrkia G. The comparision of the antimicrobial effect of P. harmala smoke and hydrogen peroxide on hospital germs. complementary Medicine Journal. 2017;7(2):1897-905. eng.
Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology. 2011;163(7):1344-64.
Nissen L, Zatta A, Stefanini I, Grandi S, Sgorbati B, Biavati B, et al. Characterization and antimicrobial activity of essential oils of industrial hemp varieties (Cannabis sativa L.). Fitoterapia. 2010;81(5):413-9.
Yang Z, Wu N, Zu Y, Fu Y. Comparative anti-infectious bronchitis virus (IBV) activity of (-)-pinene: effect on nucleocapsid (N) protein. Molecules. 2011;16(2):1044-54.
Fouladi Fard R, Farajinia M. Effect of Medicinal Smokes on Reduction of Fungal Indoor Air Contamination. Journal of Environmental Health and Sustainable Development. 2016;1(3):128-33.
Tabrizizadeh M, Zandi H, Mosaddegh Mehrjardi M, Mahmodizadeh H. Comparing the Antibacterial Effect of Peganum Harmala Extract and 5/25% Sodium Hypochlorite on Enterococcus Faeclis Biofilm. The Journal of Shahid Sadoughi University of Medical Sciences. 2014;22(3):1256-64.
Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasari W, Widyawaruyanti A, et al. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. Journal of Natural Medicines. 2008 2008/10/01;62(4):470-2.
Tayel AA, Shaban SM, Moussa SH, Elguindy NM, Diab AM, Mazrou KE, et al. Bioactivity and application of plant seeds’ extracts to fight resistant strains of Staphylococcus aureus. Annals of Agricultural Sciences. 2018;63(1):47-53.
Bibi F. Diversity of antagonistic bacteria isolated from medicinal plant Peganum harmala L. Saudi Journal of Biological Sciences. 2017;24(6):1288-93.
Fatma B, Fatiha M, Elattafia B, Noureddine D. Phytochemical and antimicrobial study of the seeds and leaves of Peganum harmala L. against urinary tract infection pathogens. Asian Pacific Journal of Tropical Disease. 2016;6(10):822-6.
Abdulridha MM, Abdulhussein HS, Alyaseen FF, Hassan BA. Phytochemical and Antibacterial Activity of The Pegnum Harmala Seeds and Its Alkaloids. Plant Archives. 2019;19(1):1439-44.
Parvin N, Validi M, Banitalebi M, Mobini GR, Ashrafi K, Farrokhi E, et al. Effect of medicinal smokes on some nosocomial infection factors. Journal of Shahrekord Uuniversity of Medical Sciences. 2010;12.
Ma X, Liu D, Tang H, Wang Y, Wu T, Li Y, et al. Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds. Acta Biochimica et Biophysica Sinica. 2012;45(2):87-94.
Niroumand MC, Farzaei MH, Amin G. Medicinal properties of Peganum harmala L. in traditional Iranian medicine and modern phytotherapy: a review. Journal of Traditional Chinese Medicine. 2015;35(1):104-9.
Arzani A. Qarabadin Ghaderi. Tehran: Mohammadi Publication. 1861.
Moradi M-T, Karimi A, Fotouhi F, Kheiri S, Torabi A. In vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus. Avicenna J Phytomed. 2017;7(6):519-30.
Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M, Akhlaghi M. Flor de Citrus aurantium e ansiedade pré-operatória. Revista Brasileira de Anestesiologia. 2011;61:707-12.
Moradi M-T, Karimi A, Rafieian-Kopaei M, Fotouhi F. In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus. Microbial Pathogenesis. 2017;110:42-9.
Benzekri R, Bouslama L, Papetti A, Hammami M, Smaoui A, Limam F. Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound. Microbial Pathogenesis. 2018;114:291-8.
Chen D, Tian X, Zou X, Xu S, Wang H, Zheng N, et al. Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway. International Immunopharmacology. 2018 2018/07/01/;60:111-20.
Kiani SJ, Shamsi Shahrabadi M, Ataei A, Sajjadi N. Peganum harmala seed extract can prevent HSV-1 replication in vitro. Iranian Journal of Virology. 2007;1(4):11-6. eng.
Faridi P, Ghasemi Y, Mohagheghzadeh A. Chemical composition of Peganum harmala smoke and volatile oil. Journal of Essential Oil Bearing Plants. 2013;16(4):469-73.
Edziri H, Mastouri M, Mahjoub M, Patrich G, Matieu M, Ammar S, et al. Antibacterial, antiviral and antioxidant activities of aerial part extracts of Peganum harmala L. grown in Tunisia. Toxicological & Environmental Chemistry. 2010;92(7):1283-92.
Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. 2013;7(14):199-212.
Asgarpanah J, Ramezanloo F. Chemistry, pharmacology and medicinal properties of Peganum harmala L. African Journal of Pharmacy and Pharmacology. 2012;6(22):1573-80.
Hayet E, Maha M, Mata M, Mighri Z, Laurent G, Mahjoub A. Biological activities of Peganum harmala leaves. African Journal of Biotechnology. 2010;9(48):8199-205.
Abdi S, Ali A. Role of ROS modified human DNA in the pathogenesis and etiology of cancer. Cancer Letters. 1999;142(1):1-9.
Fukuchi K, Sakagami H, Okuda T, Hatano T, Tanuma S-i, Kitajima K, et al. Inhibition of herpes simplex virus infection by tannins and related compounds. Antiviral Research. 1989;11(5):285-97.
Guillén MD, Manzanos MJ. Composition of the extract in dichloromethane of the aerial parts of a Spanish wild growing plant Thymus vulgaris L. Flavour and Fragrance Journal. 1998;13(4):259-62.
Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology. 1999;64(3):235-40.
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