An Evaluation of Antidepressant-Like Effects of the Aqueous Extract of the Myrtus Communis L. Fruit in Male Mice
Abstract
Background and Aim: This study aimed to investigate the potential antidepressant-like effect of aqueous extract from fruits of M.Communis L. on mice. Materials and Methods: To carry out this investigation, after weighting, coding, and classifying the mice, they were divided into the following groups (n = 6): test groups (175, 350, and 700 mg/kg of M. Communis aqueous extract; i.p), the control group (20 mg/kg Fluoxetine, and 30 mg/kg Imipramine; i.p) and the blank group (normal saline i.p). Different doses of the extract, fluoxetine, and Imipramine were administrated daily for 28 days. Behavioral evaluations were performed using the tail suspension and forced swimming tests. Results: The aqueous extract of the M. Communis fruit did not reduce the immobility time in both TST and FST(P>0.05). Moreover, the extract did not increase the climbing behavior in FST, which reveals the depressant-like effect of this herbal extract (P>0.05). This depressant-like effect increased dose-dependently. Conclusion: The results of this study suggest that the aqueous extract of the M. Communis fruit has a depressant-like activity in mice models.References
Pardo M, Miller RD. Basics of Anesthesia. 7th ed. Philadelphia, Elsevier. 2018.
Constant I, Nghe MC, Boudet L, Berniere J, Schrayer S, Seeman R, et al. Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables. Br J Anaesth. 2006;96(5):614-9.
Duke J. Anesthesia Secrets. 5th ed. Philadelphia, Mosby. 2011.
Dinis-Oliveira RJ. Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017;2(1):2-10.
Abdi-Azar H, Abbasi Maleki S. Comparison of the anesthesia with thiopental sodium alone and their combination with Citrus aurantium L. (Rutaseae) essential oil in male rat. Bull Env Pharmacol Life Sci. 2014:37-44.
Yarmohammadpoor-Beneh- Khalkhal M, Abbasi Maleki S, Bakhtiarian A. Evaluation of the Effects of Co-administration of Humulus lupulus hydroalcoholic Extract with Ketamine on Anesthetic Parameters in Male Rat. SJIMU. 2018;25(5):108-9.
Bome Amirhajloo A, Abbasi Maleki S. Comparison of the anesthesia with Co-administration of Passiflora incarnata hydroalcoholic extract- ketamine with diazepam-ketamine in male rat. J Fasa Univ Med Sci. 2017;7(2):275-82.
Abbasi Maleki S, Farahpour MR, Alinasab P,editors. Comparison of the anesthesia with combination of Rosa damascena essential oil-Ketamine with Diazepam – Ketamine in male rat,6th European Congress of Pharmacology (EPHAR 2012); 17-20 Jul 2012; Granada,Spain: British Pharmacological Society; 2012.p.13.
Peter ID, Sandabe UK, Adamu JY. Aqueous leaf extract of Olea hochstetteri modulates thiopentone- and ketamine-induced anesthesia in rats. J Exp Integr Med. 2013;3(2):141-4.
Yousefi F, Abbasi Maleki S, Najafizadeh P. The phytochemical and anesthesia effects of Myrtus communis essential oil co-administration with thiopental in male rat. J Shahrekord Univ Med Sci. 2018;20(4):87-99
Al-Saghir MG. Evolutionary History of the Genus Pistacia (Anacardiaceae). Int J Botany.2009;5:255-7.
Shahraki J, Zareh M, Kamalinejad M, Pourahmad J. Cytoprotective effects of hydrophilic and lipophilic extracts of Pistacia vera against oxidative versus carbonyl stress in rat hepatocytes. Iran J Pharm Res. 2014;13(4):1263-77.
Tomaino A, Martorana M, Arcoraci T, Monteleone D, Giovinazzo C, Saija A. Antioxidant activity and phenolic profile of pistachio (Pistacia veraL., variety bronte) seeds and skins. Biochimie. 2010; 92(9):1115-22.
Ahmad NS, Waheed A, Farman M, Qayyum A. Analgesic and anti-inflammatory effects of Pistacia integerrimaextracts in mice. J Ethnopharmacol. 2010;129(2):250-3.
Parvardeh S, Niapoor M, Hosseinzadeh H. Hepatoprotective activity of Pistacia vera L. gum extract in rats. J Med Plants. 2002;1(4):27-34.
Ziaee T, Hosseinzadeh, H. Muscle Relaxant, Hypnotic and Anti-anxiety Effects of Pistacia vera gum Hydroalcoholic Extract in Mice. J Med Plants. 2010;9(36):96-105.
Hedenqvist P, Roughan JV, Fleknell PA. Effects of repeated anesthesia with ketamine/medetomidine and preanesthetic administration of buprenorphine in rats. Lab Anim. 2000;34:207-11.
Bozorgi M, Memariani Z, Mobli M, Salehi Surmaghi MH, Shams-Ardekani MR, Rahimi R. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. Scientific World Journal. 2013;219815.
Baytop T. Therapy with medicinal plants in Turkey. Istanbul University press, Istanbul. 1984.
Hosseinzadeh H, Behravan E, Soleimani M. Antinociceptive and Anti-inflammatory Effects of Pistacia vera Leaf Extract in Mice. Iran J Pharmaceuti Res. 2011;10(4):821-8.
Parvardeh S, Niapoor M, Nassiri Asl M, Hosseinzadeh H. Antinociceptive, anti-inflammatory and acute toxicity effects of Pistacia vera L. gum extract in mice and rat. J Med. Plants. 2002;1(4):58-67.
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