Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 8 1 2023 05 01 An Investigation of the Protective Effects of the Hydroalcoholic Extract of Persian Yellow Rose (Rosa foetida Herrm.) on Rats with Parkinson's Disease Induced by 6-Hydroxydopamine 1 16 221042 10.22087/hmj.v8i1.964 EN Nahid Jivad Department of Neurology, School of Medicine, Kashani Hospital, Shahrekord University of Medical Sciences Zahra Forouzandeh Shahraki Deputy of Technology and Research, Shahrekord University of Medical Sciences, Shahrekord, Iran Amir Mahdi Naseri Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran Journal Article 2025 05 18 Background and Aim: This study was carried out to investigate the protective impacts of Rosa foetida extract on Parkinson's disease. Materials and Methods: Seventy rats were divided into 7 groups of 10, including a sham group, the Parkinsonian group (received 6OHDA), pretreatment and post-treatment groups with Persian yellow rose extract (150 mg/kg and 300 mg/kg), and the positive control (L-DOPA). Animal behavior was evaluated using behavioral tests, including muscle stiffness test, rotarod, and elevated body swing test (EBST). The data were analyzed using SPSS statistical software. Results: The frequency of turning to the right in the EBST test, the muscle stiffness score, and the right as well as left-hand scores in the muscle stiffness test were significantly higher in the Parkinsonian group than in the sham group (P<0.05). The frequency of turning to the right in the post-treatment group with Persian yellow rose extract in doses 150 and 300 mg/kg and in pre-treatment with Persian yellow rose extract in dose 300 was significantly lower than that of the Parkinsonian group (P<0.05). The score of the left and right hand in the pre-treatment group of Persian yellow rose extract at a dose of 300 significantly decreased compared with the Parkinsonian group (P<0.05). The time to maintain balance in the rotarod test was significantly reduced in the Parkinsonian group compared with the sham, and post-treatment as well as pre-treatment groups with different doses of Persian yellow rose extract (P<0.05). Conclusion: According to the results of this study, it can be said that the Persian yellow rose extract protects nerve cells against oxidative damage caused by 6-hydroxydopamine and improves motor symptoms and balance disorders caused by Parkinson's disease.  https://hmj.lums.ac.ir/article_221042_69b2772cf02b7e5162ce4fcf805a9b4e.pdf