Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 2 3 2017 05 01 The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart 105 113 221544 EN Mehrnoush Moghaddasi 1 Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran 2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Majid Taati Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran Hasan Noroozi 1 Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran 2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Sam Bamani Lirgeshasi Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Soheila Pourkhodadad Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Bahram Delfan Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Afshin Nazari 1 Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran 2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Ira Journal Article 2025 05 24 Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied.Materials and Methods: The right carotid artery was occluded with a 5-0 silk suture and the left carotid artery was occluded after a week. The olive (Olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. The sham and hypoperfusion groups were fed with normal saline. Each group had 6 rats. After 25 days, electrophysiological heart parameters, i.e. HR, QTc, QRS duration, QT interval, PR interval, RR interval, ST amplitude, T wave amplitude and also the thickness of left ventricle (TLV) were assessed.Results: The administration of olive leaf extract (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ECG changes (such as shortening of PR, QRS, QT and QTc intervals, prominent T waves and ST elevation). Moreover, olive leaf extract (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after cerebral hypoperfusion.Conclusion: Our results indicated that post-treatment with ethanolic extract of olive leaves could prove beneficial effects in managing the cerebral hypoperfusion-induced cardiac abnormality in rats. https://hmj.lums.ac.ir/article_221544_c4071816f4128416ecad119f96fcbc35.pdf