Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 10 1 2025 01 01 Attenuation of LPS-Induced Oxidative Stress in the Rats' Brains by Olive Leaf Extract 231631 10.22087/hmj.2025.231631 EN Zahra Davoudabadi School of Veterinary Medicine, Lorestan University, Khorramabad, Iran Maryam Ghanbari Asl School of Veterinary Medicine, Shiraz University, Shiraz, Iran Masoud Alirezaei Lorestan University Department of Basic Sciences, Division of Biochemistry Khorramabad, Iran 0000-0003-1022-8896 Alireza Rocky Department of Clinical Sciences, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran Journal Article 2024 11 16 Background and Aim: Today, oxidative stress and its association with neurological disorders have drawn researchers' attention. This study aimed to investigate the antioxidant effects of olive leaf extract (OLE) on oxidative stress induced by lipopolysaccharide (LPS) in rats' brains. Materials and Methods: Twenty-eight adult male Sprague-Dawley rats were divided into four equal groups: control, LPS, and two OLE-pretreated plus LPS groups. The OLE-pretreated groups received OLE (40 and 60 mg/kg body weight as orally) and normal saline for 10 consecutive days. All groups, except the control group, received LPS (once; 5 mg/kg intraperitoneally) on the 11th day of treatment. The antioxidant status of the brain was measured using a lipid peroxidation marker (MDA) and the activities of antioxidant enzymes. Results: Lipid peroxidation significantly increased in the LPS group in comparison with the control and OLE60+LPS groups. GSH content and glutathione peroxidase (GPx) activity significantly increased in the LPS group compared with the control and OLE60+LPS groups. Conclusion: These results suggest that OLE partially attenuates LPS-induced oxidative stress in the rats' brains.

https://hmj.lums.ac.ir/article_231631_9851e2a7a7a813af28d607783f7c904d.pdf