Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 10 1 2025 01 01 Effects of Satureja khuzestanica jamzad Supplementation on Inflammatory and Antioxidant Indicators in Type 2 Diabetes Patients: A Randomized Controlled Clinical Trial (RCT) 231633 10.22087/hmj.2025.231633 EN Sajjad Roosta Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Maryam Bordbar Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Yaser Mokhayeri Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran Fatemeh Ghasemi Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Saeed Choobkar School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Hamidreza Nikbakht Boyerahmad Health center, Yasuj University of Medical Sciences, Yasuj, Iran Ebrahim Falahi Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran 0000-0001-9615-1089 Journal Article 2024 11 12 <strong>Background and Aim:</strong> As the most common metabolic disorder, type 2 diabetes mellitus is growing exponentially worldwide. <em>Satureja khuzestanica </em>(SK)<em> </em>is a native plant of Iran that grows widely in southern Iran. Various animal studies have reported its antimicrobial, antioxidant, anti-inflammatory, and pain-relieving effects to date. The present research aimed to investigate the impact of the daily consumption of SK on inflammatory (IL-6, CRP) and antioxidant indicators (catalase, glutathione peroxidase, glutathione reductase, superoxide dismutase and total antioxidant capacity) in type 2 diabetic patients.<br><strong>Materials and Methods:</strong> In a double-blind, placebo-controlled clinical trial, 78 patients (44 females and 34 male) with type 2 diabetes were included and randomly divided into two groups. One group received SK (capsule containing 500 mg) and the other group received placebo (500 mg talcum powder) once a day for 12 weeks. After the intervention, inflammatory and antioxidant indicators of the two groups were compared.<br><strong>Results:</strong> The levels of total antioxidant capacity, superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase were remarkably distinct between the intervention and placebo groups, and these antioxidant indices were higher in the intervention group (P<0.05). Moreover, a considerable decrease in weight, CRP and IL-6 levels were observed in patients in the <em>S. khuzestanica</em> group.<br><strong>Conclusion:</strong> As the findings of the study revealed, SK supplementation might improve the antioxidant and inflammatory indices of patients with T2DM. The results of this study could potentially offer new additional therapies for diabetes complications with no adverse side effects. These results should be further confirmed in clinical trials. https://hmj.lums.ac.ir/article_231633_568d395737b48f398fef8bb1c42d0f34.pdf