Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 10 3 2025 07 12 The Effect of Chamomile Extract on Histopathological and Biochemical Changes of Fertile Female Dieabetic Rats 235423 10.22087/hmj.2025.558364.1023 EN Foroogh Namjoyan Pharmacognosy Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 0000-0002-3171-479X Mohamad Ebrahi Azemi Department of Pharmacognosy, Medicinal Plant and Natural Product, Research Center, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran 0000-0001-7737-8683 Mohammad Javad Khodayar Toxicology Research Center, Department of Toxicology and Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 0000-0001-9518-1286 Esrafil Mansouri Cellular and Molecular Research Center, Department of Anatomical Sciences, School of Medicine, Ahvaz. 0000-0001-6997-6798 Azam Darvish Padok School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 0000-0001-5135-152X Fatemeh Ahmadpour Department of Clinical Biochemistry School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran 0009-0008-2595-3592 Forouzan Ahmadpour Razi Herbal Medicines Research Center, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran 0000-0002-1142-6088 Journal Article 2025 05 06 Abstract Background and Aim Matricaria Chamomilla (M.C) has different effects such as anti-inflammatory and anti-hyperglycemia. The aim of our study was to investigate effect of M.C extract on diabetic complications. Materials and Methods The animals were allocated into five groups. The first group, and the second group were healthy, and diabetic rats that received distilled water via oral gavage. The third, fourth and fifth groups were diabetic animals that received three doses of 100, 300, and 500 mg/kg chamomile within the first 17 days of pregnancy, respectively. The levels of Blood sugar (BS), and hemoglobin A1c (HbA1c) were measured in the first 17 days of pregnancy then we prepared histological samples of the kidney, liver, and uterus of mother rats, and the neural tube of the fetus at the end of the study. Results The chamomile extract significantly reduced the HbA1c and BS levels at the end of the 17th day (P ≤ 0.01) in the intervention groups. Also, the severity of diabetic damage in the liver and placenta was reduced in treated diabetic rats with M.C, but not reduced in the kidney. MC could cause dilatation of the central spinal canal, and spinal cord edema that may indicate the teratogenic effect on the fetus. Conclusions Chamomile has beneficial effects on the control of BS, and prevention of liver and placental tissue damage. Chamomile also has maybe teratogenic effects on the fetus, and it is not recommended for pregnant women.

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