Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 10 4 2025 10 01 Impact of Curcumin–Piperine Supplementation on Sleep Quality and Gastrointestinal Symptom Severity in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial 235782 10.22087/hmj.2025.552376.1009 EN Ezatollah Fazeli Moghadam Nutritional Health Research Center, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. 0000-0001-6322-4229 Anita Fazeli Moghadam Nutritional Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. 0009-0006-1113-2924 Fateme Cheshmi Nutritional Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. Rasool Mohammadi Nutritional Health Research Center, Health and Nutritional Department, Lorestan University of Medical Sciences, Khorramabad, Iran. Journal Article 2025 08 12 Abstract<br><br><br><br>Background: Type 2 diabetes is among the most prevalent metabolic disorders and is often accompanied by gastrointestinal problems and sleep disturbances. This study aimed to evaluate the effects of curcumin–piperine supplementation on sleep quality and gastrointestinal symptom severity in individuals with type 2 diabetes.<br><br>Methods: In a randomized, double-blind, placebo-controlled trial, 64 patients with type 2 diabetes meeting the inclusion criteria were assigned to receive either one capsule daily containing 500 mg curcumin and 5 mg piperine or a matching placebo for 12 weeks. Sleep quality and gastrointestinal symptom scores were assessed at baseline and after the intervention.<br><br>Results: Twelve weeks of curcumin–piperine supplementation resulted in significant improvements in sleep quality and duration (P = 0.022) and a marked reduction in gastrointestinal symptom severity (P = 0.000) compared with placebo. The curcumin–piperine group showed a mean improvement of −2.1 ± 1.3 in the Pittsburgh Sleep Quality Index (PSQI) score, compared with −0.7 ± 1.1 in the placebo group. Gastrointestinal symptom severity decreased by −0.9 ± 0.4 in the intervention group versus −0.2 ± 0.3 in the placebo group.<br><br>Conclusion: Curcumin–piperine supplementation may be effective in enhancing sleep quality and alleviating gastrointestinal symptoms in patients with type 2 diabetes. https://hmj.lums.ac.ir/article_235782_b759652b4fe5b46a6f55495e8e8b5210.pdf