Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 10 4 2025 10 14 Investigation of the antimicrobial effects of Loganberry (Rubus × loganobaccus) plant extract 236248 10.22087/hmj.2025.549605.1007 EN Mahboubeh Taherkhani Department of Chemistry, Tak. C., Islamic Azad University, Takestan, Iran 0000-0002-4539-5937 Shima Merikh Department of Chemistry, TeMS. C., Islamic Azad University, Tehran, Iran Journal Article 2025 08 04 Background and Aim: The hybrid Loganberry plant is not native to Iran and belongs to the Rosaceae family and the Rubus subfamily. The present study aimed to evaluate the antimicrobial properties of the extract from hybrid Loganberry (Rubus × loganobaccus) propagated via in vitro culture<br>Materials and Methods: In this study, the antimicrobial activity of Loganberry plant extract (3.12% yield) was assessed against the yeast Candida albicans and four pathogenic bacterial strains: Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Antimicrobial efficacy was determined by measuring the diameter of the growth inhibition zone, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). <br>Results: Based on the findings, the strongest antibacterial effect was observed against E. coli, with an inhibition zone diameter of 20 mm. The methanolic extract also demonstrated considerable antibacterial activity against S. aureus and P. aeruginosa, with MIC values of 1.25 mg/ml and MBC values of 5 mg/ml. Furthermore, the highest antifungal activity was recorded against C. albicans, with MIC and MBC values of 2.5 mg/ml and 5 mg/ml, respectively.<br>Conclusion: Overall, the results indicate that the methanolic extract of Loganberry leaves exhibits substantial antimicrobial potential and may serve as a promising natural source for developing antimicrobial agents. https://hmj.lums.ac.ir/article_236248_139205532eea05eecb72f5472eeddee8.pdf