Lorestan University of Medical Sciences Herbal Medicines Journal 2538-2144 9 2 2024 05 01 A Snapshot on the Development of Quinolones and Fluoroquinolones - An Origin of Nalidixic Acid 1 11 220950 10.22087/hmj.v9i2 EN Sharma Manoj Kumar School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India Kumawat Mukesh Kumar School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India Diwan Anupama School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India Sardana Satish Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India Yadav Narender School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India Kumar Brijesh Department of nursing, Patna Medical College Hospital, Patna, Bihar, India Amity College of Nursing, Amity University, Gurugram, Haryana, India Journal Article 2025 05 17 Quinolone antibacterial molecules are the most impactful types of anti-infective, active pharmaceutical<br />ingredients in our never-ending battle against pathogens. Additionally, in contrast to many anti-infective classes,<br />the discoverers published a startlingly small amount of information regarding the origin of the class or the<br />justification for this significant group's first FDA-approved agent, nalidixic acid. With an emphasis on the<br />Quantitative Structure-Activity Relationship (QSAR), chemistry, development, adverse effect, and future aspects<br />of this class of antibiotics, this article discusses the discovery, total synthetic methods, pharmacology, clinical<br />applications, and further lead to the new pipeline that produced various large selling and widely used antibiotics.<br />Keywords: Nalidixic Acid, Synthesis, Development, Quinolones, Fluoroquinolones https://hmj.lums.ac.ir/article_220950_8d4eb6d361a0db9ff389a054f248c8ed.pdf