Lorestan University of Medical SciencesHerbal Medicines Journal2538-21448420230501The Cardioprotective Effect of the Hydroalcoholic Extract of Ginger in Renovascular Hypertension Model in Male Rats1722095310.22087/hmj.v8i4.1067ENNooryazdanAramCardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.ZinivandMahtabCardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.VajiheGhorbanzadehCardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.HosseinBeyranvandRazi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Science, Khorramabad, IranAzadehKhaliliDepartment of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, IranMehrnooshSedighiCardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.MehdiBirjandiRazi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Science, Khorramabad, Iran.AfshinNazariCardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, IranJournal Article20250517Background and Aim: Many studies have been conducted worldwide to control blood pressure through herbal medicines. The present study was conducted to investigate ginger's role in the treatment of hypertension. Materials and Methods: Fifty-four male Wistar rats weighing about 200 to 250 grams were randomly divided into 6 groups (3 groups of ten, and 3 groups of eight rats) for in vivo investigation. The left renal artery was blocked using a non-allergenic stainless-steel clamp to create hypertension. Then, the hydroalcoholic extract of ginger was prepared using distilled water in three doses of 100, 200, and 300 mg/kg. Oral gavage administration was used for the rats daily for 42 days using the hydroalcoholic extract of ginger. Pulmonary blood pressure was assessed using a cuff sphygmomanometer. Electrocardiogram (EKG or ECG) and echocardiogram (echo) tests were also performed after the end of the gavage on the 42nd day. Moreover, the amount of nitric oxide (NO) in serum samples was measured using the Griess reagent system. After categorizing raw data in Excel, they were analyzed using analysis of variance (ANOVA) by SPSS software. Results: In this study, it was observed that ginger could notably decrease blood pressure. This decrease in blood pressure is due to the diuretic effect of the ginger's extract. Consequently, the use of ginger decreases the amount of NO. Furthermore, these data revealed that ginger had no toxic effect on the heart, and using this plant in hypertensive heart disease patients is safe. Conclusion: Considering the positive effects of ginger in decreasing blood pressure and its non-toxicity for the heart, it is recommended to conduct further specialized studies and clinical trials in this regard. https://hmj.lums.ac.ir/article_220953_8c498f870affb8c6151760af20ee95d3.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21448420250517A Quantitative and Qualitative Study of Fatty Acids in Ziziphus Species in Iran17220958ENMaryamKeshavarziDepartment of Plant Sciences, Faculty of Biological Sciences, Alzahra University, Tehran, IranKefayatSharifatDepartment of Plant Sciences, Faculty of Biological Sciences, Alzahra University, Tehran, IranFaezehFazeliDepartment of Biological Sciences, Shahid Rajaee Teacher Training University, Tehran, IranJournal Article20250517The genus Ziziphus belongs to the Rhamnaceae family with 70 species of trees in the world. There are three native species of this genus in Iran. The fruit of these trees is edible and has medicinal value. Ziziphus samples were gathered from natural habitats in Iran. We used cold methylation and gas chromatography to extract and identify of fatty acids. Identification of the fatty acids was carried out through the investigation of the curves.The significance of the quantitative results was evaluated using one-way analysis of variance. The study of fatty acids in pulps and seeds of the Ziziphus species showed that Oleic acid was the indicator in the studied species.Differences in the type of fatty acid were observed between the species. Examination of the fatty acids in the Ziziphus seed revealed that oleic acid is the main constituent of this oil and there is a quantitative and qualitative difference in the fat of the species. The fatty acids in seeds are higher than the fatty acids in the fruit pulp and the percentage of unsaturated fatty acids is higher than that of saturated fatty acids. The findings of this study are consistent those of with previous studies.https://hmj.lums.ac.ir/article_220958_af26a166f588e93527be39cbaef8bf6d.pdf