Lorestan University of Medical SciencesHerbal Medicines Journal2538-21448120230501An Investigation of the Protective Effects of the Hydroalcoholic Extract of Persian Yellow Rose (Rosa foetida Herrm.) on Rats with Parkinson's Disease Induced by 6-Hydroxydopamine11622104210.22087/hmj.v8i1.964ENNahidJivadDepartment of Neurology, School of Medicine, Kashani Hospital, Shahrekord University of Medical SciencesZahraForouzandeh ShahrakiDeputy of Technology and Research, Shahrekord University of Medical Sciences, Shahrekord, IranAmir MahdiNaseriStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranJournal Article20250518Background and Aim: This study was carried out to investigate the protective impacts of Rosa foetida extract on Parkinson's disease. Materials and Methods: Seventy rats were divided into 7 groups of 10, including a sham group, the Parkinsonian group (received 6OHDA), pretreatment and post-treatment groups with Persian yellow rose extract (150 mg/kg and 300 mg/kg), and the positive control (L-DOPA). Animal behavior was evaluated using behavioral tests, including muscle stiffness test, rotarod, and elevated body swing test (EBST). The data were analyzed using SPSS statistical software. Results: The frequency of turning to the right in the EBST test, the muscle stiffness score, and the right as well as left-hand scores in the muscle stiffness test were significantly higher in the Parkinsonian group than in the sham group (P<0.05). The frequency of turning to the right in the post-treatment group with Persian yellow rose extract in doses 150 and 300 mg/kg and in pre-treatment with Persian yellow rose extract in dose 300 was significantly lower than that of the Parkinsonian group (P<0.05). The score of the left and right hand in the pre-treatment group of Persian yellow rose extract at a dose of 300 significantly decreased compared with the Parkinsonian group (P<0.05). The time to maintain balance in the rotarod test was significantly reduced in the Parkinsonian group compared with the sham, and post-treatment as well as pre-treatment groups with different doses of Persian yellow rose extract (P<0.05). Conclusion: According to the results of this study, it can be said that the Persian yellow rose extract protects nerve cells against oxidative damage caused by 6-hydroxydopamine and improves motor symptoms and balance disorders caused by Parkinson's disease. https://hmj.lums.ac.ir/article_221042_69b2772cf02b7e5162ce4fcf805a9b4e.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21448120230501Identification of Medicinal Plants Used to Enhance Appetite and Increase Weight in Aligudarz, Lorestan Province: An Ethnobotanical Study172522104310.22087/hmj.v7i4.1054ENMasoomehAbdiRazi Herbal Medicines Research Center, Aligudarz School of Nursing, Lorestan University of Medical Sciences, Khorramabad, IranKioumarsKaramizadehRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IranIrajSalimi KiaDepartment of Pharmacognosy, School of Pharmacy, Razi Herbal Medicines Research Center, Lorestan University of Medical
Sciences, Khorramabad, IranElaheSarlakRazi Herbal Medicines Research Center, Aligudarz School of Nursing, Lorestan University of Medical Sciences, Khorramabad, IranJournal Article20250518Background and Aim: Anorexia is a disorder that can be annoying for patients in prolonged cases. It can lead to health-threatening problems. Today, different methods are used to increase appetite and weight. One of these methods is the use of medicinal plants. This study was conducted with the aim of investigating the medicinal plants used to increase appetite and weight in Aligoudarz, Lorestan, Iran. Materials and Methods: The present study is descriptive research. Sampling was carried out using the complete enumeration method, and 20 medicinal plant sellers took part in this study. Data were collected using a two-part questionnaire containing demographic characteristics form and characteristics of the medicinal plants used in the study. Results: The results of the study indicated that 17 medicinal plants belonging to 11 plant families could strengthen appetite and increase weight. The most abundant plant recommended by the medicinal plant sellers was alfalfa (25.71%), followed by wheat (14.28%). In terms of the plant family, the most used plants were related to the Poaceae family (18%), followed by Asteraceae (17%) and Apiaceae (17%). Conclusion: Iran is a rich country in the field of medicinal plants, it is recommended to identify plants related to appetite enhancement and weight gain through review studies and then conduct laboratory studies to confirm their effect so that consumers can use these plants with more scientific support. https://hmj.lums.ac.ir/article_221043_be2b2ea343a6d58275ee993bfa97b90a.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21448120230501The Effect of the Hydroalcoholic Extract of Quercus infectoria Fruit Hulls (Jaft-E-Baloot) on Formalin-Induced Inflammation and Pain in Male Mice263322105010.22087/hmj.v8i1.1011ENAliKarimianStudent Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranAmirhosseinNafariStudent Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranAmirmehdiSarvestaniStudent Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranAmirZamaniStudent Research Committee, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, IranNimaBehnaminiaStudent Research Committee, Kashan University of Medical Sciences, Kashan, IranRasoolMohammadiRazi Herbal Medicines Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, IranMohammadAlmasianSchool of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranAli AsgharKianiDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Lorestan University of Medical Sciences,
Khorramabad, IranJournal Article20250518Background and Aim: Herbal medicines have been used to alleviate inflammation and pain since ancient times, and their use is even on the rise. The Quercus infectoria plant has been commonly used for many years to treat inflammation and pain in alternative medicine. Various species and different parts of this plant have been studied. The present study aimed to investigate the anti-inflammatory and analgesic properties of the extract of the fruit hulls of Q. infectoria to find a plant-based alternative to the available drugs with fewer side effects. Materials and Methods: This study used 60 male NMRI mice with a weight range of 35-40 g. The mice were randomized into a negative control group which only received formalin, a positive control group that received diclofenac 200 µg/kg, and four experimental groups that received 50, 100, 150, and 200 mg/kg of the fruit hulls extraction. Formalin was injected into the paws of the mice to induce inflammation and pain. Then, the paw volume was measured during the first three hours after injection with a digital Plethysmometer. Pain score was also evaluated in three stages at 60-minute intervals. Results: The results showed that the fruit hulls extract could reduce inflammation at all doses, particularly at 200 mg/kg in comparison with the negative control group (p < 0.001). Moreover, the fruit hulls extract relieved pain at different doses in acute and chronic stages. Conclusion: The fruit hulls extract alleviated the pain and reduced the inflammation in mices' paws depending on the dose. Therefore, it can be considered as a possible alternative to chemical drugs. https://hmj.lums.ac.ir/article_221050_4bf745ea6b454023c7f6004a0e584ef2.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21448120230501An Evaluation of Anti-Microbial Properties of Gelatin and Collagen Films Enriched by Aloe Vera and Henna to Build an Organic Band Aid495822105310.22087/hmj.v8i1.1000ENBayanKhoshkalamDepartment of Biology, Payame Noor University, Tehran-Shargh, Iran.RaminManaffarDepartment of Biotechnology, Artemia and Aquatic Animals Research Institute, Urmia University, IranNooshinSohrabiMycology Research Centre, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.NabiKhaliliaqdamDepartment of Agriculture, Payame Noor University, Tehran, Iran.Journal Article20250518Today, the idea of using biodegradable polymers which can naturally replace skin shortly before skin repair while also inhibiting the growth of bacteria causing wound infection is of great interest. The purpose of this study was to investigate the possibility of making degradable films using natural compounds, including chicken gelatin and collagen, henna plant extract, and aloe vera gel. Materials and Methods: Aloe vera gel and ethanolic extract of the henna plant were prepared and their antioxidants were studied by DPPH (Diphenylpicrylhydrazyl) free radical-scavenging assay. Then, the antimicrobial properties of henna extract and aloe vera gel were evaluated against Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the disk diffusion method along with the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. To prepare the films, the gelatin and collagen extracted from chicken, along with the ethanolic extract of henna and aloe vera gel, was used. Subsequently, the physicochemical and mechanical properties (elasticity, dissolution potency, and moisture level and microscopy investigation) of the films as well as the antimicrobial properties of films against these microbes were investigated. Results: The results revealed that the anti-microbial effects of henna extract and aloe vera gel alone and in combination with gelatin/collagen matrix varied and had different effects on the tested microbes. Moreover, aloe vera showed stronger antioxidant properties than henna. Conclusion: When synthesizing gelatin/collagen-based biopolymers, plant compounds and extracts can be used to enhance the antioxidant and antibacterial properties and apply organic band aids to help heal wounds and prevent wound infections. https://hmj.lums.ac.ir/article_221053_03e772ba6de276701c534ee09ce9463c.pdf