Lorestan University of Medical SciencesHerbal Medicines Journal2538-21443420180501Evaluation of Effectiveness of Ethanolic Extract of Curcuma longa, discretely and in Combination with Chloroquine against Chloroquine-Sensitive Strain of Plasmodium berghei13313822134610.22087/herb%20med%20j.v3i3.741ENPeymanHeydarian1 Scientific research center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Parasitology and Mycology, School of Medicine, Qazvin, University of Medical Sciences, Qazvin, IranMehdiNateghpour3 Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 Research Center of Quran, Hadith and Medicine, Tehran University of Medical Sciences, Tehran, IranNahidehMazhariDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranAfsanehMotevalli HaghiDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranLeilaFarivaDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranEffatSouriDepartment of Pharmaceutical Chemical, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAmirrezaJavadi MamaghaniDepartment of Parasitology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranBahmanRahimi EsboeiDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranJournal Article20250520Background and Aim: Malaria is a parasitic disease and one of the most important public health problem. Chemical medications such as chloroquine, primaquine, pyrimethamine, mefloquine, artemisinin and fansidar are commonly used to treat malaria but most of the antimalarials have encountered with problem of drug resistance. Therefore, new therapeutic materials are promptly needed. During many years natural medicines, especially medicinal plants have been considered as the pivotal means for treatment of malaria in some endemic areas. In this study, we evaluated the effectiveness of ethanolic extract of Curcuma longa L, discretely and in combination with chloroquine against chloroquine-sensitive strain of Plasmodium berghei.Materials and Methods: Fifty percent effective dose (ED50s) of C. longa and chloroquine were determined according to peter̛ s method. Then based on the obtained ED50s combination of Curcuma longa and chloroquine with different ratios were examined against the strain.Results: The results of ED50s for chloroquine and C. longa were 1.4mg/kg and 1250mg/kg, respectively. Combination of C. longa ethanolic extract with chloroquine in ratio of 80/20 showed the highest activity with 71.75% to inhibit the growth of P. berghei indicating synergistic interaction in the combination treatment.Conclusion: It appears that turmeric (C. longa) extract is an effective anti-malarial substance especially in combination with chloroquine. https://hmj.lums.ac.ir/article_221346_5ac20b12787894551f2b5d2fda334b4f.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21443420180501Investigation of Effects of Cynodon Dactylon Aqueous Extract on the Mice Model Ulcerative Colitis13914622134710.22087/herb%20med%20j.v3i4.694ENAbolfazlAbbaszadehDepartment of Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranShahsanamGheibiMaternal and Childhood Obesity Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranLeilaZareiRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IranHadiEsmaeili Gouvarchin GhalehApplied Virology Research Center, Baqiyatallah University of Medical Science, Tehran, IranJournal Article20250520Background and Aim: Cynodon dactylon (C. dactylon) has long been examined for its anti-inflammatory properties. A type of Inflammatory Bowel Disease (IBD) is Ulcerative Colitis (UC). This study investigated the impacts of C. dactylon on the inflammatory mediators of UC induced by acetic acid in Wistar rats.Materials & Methods: The experiment was conducted on 50 male Wistar rats grouped into five equal individuals. Excluding Group I (negative control), acetic acid was used to induce UC in the rats. The treatments received different doses of C. dactylon extract, namely Group II (1 mL of 200 mg/kg orally per day, Group III (1 mL of 200 mg/kg as intra-colonic), Group IV (1 mL of intra-colonic 10 mg/kg Mesalazine), and Group V (1 mL of normal saline) as positive control. The whole treatments lasted for 10 successive days. At completion of the study, intestinal tissue and blood samples were taken from sacrificed rats. Measured parameters were inflammatory mediators, myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and activities of cytokines TNF-α and IL-6.Results: A more remedial advantage of C. dactylon extract in two forms of trans-rectal and oral administration was observed on damaged colonic tissue induced by acetic acid with reduced activities of MPO, SOD and GPx. Amounts of TNF-α and IL-6All were lowered by all treatments. Mesalazine and C. dactylon extract were not significantly different in terms of gross damages. Conclusions: Our observations indicate that C. dactylon extract with anti-colitis property can be regarded as an appropriate candidate and a natural source of current medications.https://hmj.lums.ac.ir/article_221347_25346f343438de3bfff4bf6588040982.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21443420180501The Green Synthesis and Characterization of Zinc Oxide Nanoparticles from the Leaf Extracts of Satureja hortensis14715322134810.22087/herb%20med%20j.v3i4.696ENSeyed Mahmoud RezaTaherianDepartment of Environment, Kermanshah Branch, Islamic Azad University, Kermanshah, IranSeyed AhmadHosseiniDepartment of Environment, Kermanshah Branch, Islamic Azad University, Kermanshah, IranAliJafariDepartment of Health Environmental Engineering, Lorestan University of Medical Science, Khorramabad, IranAlirezaEtminanDepartment of Breeding plant, Kermanshah Branch, Islamic Azad University, Kermanshah, IranJournal Article20250520Introduction: Zinc oxide nanoparticles are widely used in various industrial and medical fields. In order to prevent and reduce the environmental effects of commercial nanoparticles synthesized via conventional chemical methods, this study was aimed to prepare green synthesized zinc oxide nanoparticles using Satureja hortensis.Materials and Methods: In this study, the aqueous extracts of the Satureja plant were prepared as a reducing agent. ZnO nanoparticles were synthesized using zinc nitrate and sodium hydroxide. The powder samples were analyzed using an infrared spectroscopy (UV-Vis), scanning electron microscopy (SEM), Energy-dispersive X-ray analysis (EDX) and X-ray diffraction (XRD).Results: The finding such as the change in solvent color, the absorption spectrum at 330 nm, electron microscopy images, the determination of zinc and oxygen as the main elements in the composition and the peaks in the X-ray diffraction spectrum confirmed the synthesis of zinc oxide nanoparticles.Conclusion: Green synthesis of nanoparticles using plants is easier to use and non-toxic, more environmentally friendly and should be replaced with physical and chemical methods of synthesis of nanoparticles.Key Words: Savory summer plant, Satureja hortensis, Green Synthesis , ZnO Nanoparticle https://hmj.lums.ac.ir/article_221348_b257b654018c389d09b953842bae9e89.pdfLorestan University of Medical SciencesHerbal Medicines Journal2538-21443420180501A Comparison of the Effects of the Hydro-Alcoholic and Aqueous Extracts of Aloe Vera on the Proliferation of MCF715416122135010.22087/herb%20med%20j.v3i4.681ENLeilaZareiDepartment of Anatomical Sciences, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, IranSeyyed MeysamAbtahi FroushaniDepartment of Microbiology, Veterinary Faculty, Urmia University, Urmia, IranMohammedAbkhazFajrmako Hospital, Urmia University of Medical Sciences, Urmia, IranNedaEslamiDepartment of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, IranJournal Article20250520Background: Breast cancer is the most common cancer and the second leading cause of cancer death among women. Regarding that chemotherapy drugs are often associated with adverse effects on the patients. Common medicinal therapies for breast cancer have often short term effects and some of them lead to drug resistance. The target of this study is to determine the effects of aqueous and hydro-alcoholic extract of Aloe Vera on MCF 7 cells. Materials and Methods: After culturing MCF7 cancer cells in the PRMI 1460 medium, both aqueous and hydro-alcoholic extract of Aloe Vera was prepared in concentrations of 20, 40, 60, 80 and 100 μg/mL from bulk solution. Then MCF7 cells were contacted with different concentration of prepared extract. The MTT test and Acridine Orange / Propidium Iodide (AO/PI) stained was used to determine the survival rate of cells. Doxorubicin (0.1 Mm) was used as positive control. The T-Student test was used in order to analyze the data using SPSS 21. p< 0.05 was considered as significant level. Result: The results of MTT assay and viability showed that different concentrations of ethanol extracts of Aloe Vera plant to the concentration of the extract significantly and dose-dependently decreased cell proliferation of MCF7 gets (p < 0.05). Conclusion: It seems should be considered that hydro alcoholic extract can be used as a natural compound in the treatment of breast cancer. https://hmj.lums.ac.ir/article_221350_c0ee73702ba3abef14158ee50f84e5c1.pdf