A Short Review of Allium jesdianum Boiss. & Buhse (Amaryllidaceae)

  • Saeed Mohsenzadeh* Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Keywords: Allium jesdianum, Medicinal herb, Endophytes, Phytochemicals, Pharmaceutical preparations

Abstract

Background and Aim: Allium jesdianum Boiss. & Buhse (Bon-e-Sorkh or Yazdi onion in Persian) is one of Iran's important endemic and threatened plants belonging to the genus Allium. It grows at high altitudes (1800‒2600 m) in Zagros Mountains, where locals use the bulbs and aerial parts of the plant to treat colds, stomachaches, rheumatic pains, moisture diseases, and kidney problems. There is little research that highlights the chemical composition and biological activities of this medicinal herb. This review outlines the available literature on morphological characteristics, chemical composition, and medicinal uses of the Allium jesdianum. Materials and Methods: Google Scholar, PubMed, Scopus, Web of Science, and local databases were searched to find relevant articles published in these databases from 1996 to 2023. Results: Various climatic and environmental factors can affect the chemical composition of Allium jesdianum. Bon-e-Sorkh possesses several medicinally significant activities such as antioxidant, anti-inflammatory, analgesic, antidiabetic, antibacterial, antifungal, anti-hepatic, anti-nephrotoxicity, anticancer, anti-Alzheimer's, antiplatelet, anti-anxiolytic, nephrolithiasis, protoscolicidal, and anti-toxicity activities. Conclusion: Investigators should complete further research to prove or confirm the results of previous studies reported in this paper by conducting more in vitro studies, and then in vivo as well as clinical studies if the results are promising.

References

Khan N, Friesen N, Sultan A, Fritsch RM, Khan T, Ishaq K. Allium sulaimanicum: A new Allium species and section from Pakistan. Front Plant Sci. 2022;13:1020440.

Yang J, Kim S-H, Gil H-Y, Choi H-J, Kim S-C. New insights into the phylogenetic relationships among wild onions (Allium, Amaryllidaceae), with special emphasis on the subgenera Anguinum and Rhizirideum, as revealed by plastomes. Front Plant Sci. 2023;14:1124277.

Li Q-Q, Zhou S-D, He X-J, Yu Y, Zhang Y-C, Wei X-Q. Phylogeny and biogeography of Allium (Amaryllidaceae: Allieae) based on nuclear ribosomal internal transcribed spacer and chloroplast rps16 sequences, focusing on the inclusion of species endemic to China. Ann Bot. 2010;106:709–33.

Asemani Y, Zamani N, Bayat M, Amirghofran Z. Allium vegetables for possible future of cancer treatment. Phytother Res. 2019;2019:1–21. https://doi.org/10.1002/ptr.6490.

Petropoulos SA, Gioia FD, Polyzos N, Tzortzakis N. Natural antioxidants, health effects and bioactive properties of wild Allium species. Curr Pharm Des. 2020;26:1816‒37.

Alidadi H, Shirani M, Samimi A, Salimi A, Ashtari A, Khorsandi L. A. jesdianum extract induces oxidative stress and necroptosis in human colorectal cancer (HT-29) cell line. Braz Arch Biol Technol. 2021;64:e21200491.

Yazdanian E, Golkar P, Vahabi MR, Taghizadeh M. Elicitation effects on some secondary metabolites and antioxidant activity in callus cultures of A. jesdianum Boiss. & Buhse.: Methyl Jasmonate and Putrescine. Appl Biochem Biotechnol. 2022;194:601–19.

Ghasemi Pirbalouti A. Phytochemical and bioactivity diversity in the extracts from bulbs and leaves of different populations of A. jesdianum, a valuable underutilized vegetable. Acta Sci Pol Hortorum Cultus. 2019;18(2):115–22.

Mehrnia M, Hosseini Z. Popular and famous vegetation in traditional medicine of Lorestan province. Herb Med J. 2020;5(3):100‒12.

Esmaeili M, Ebrahimi Kahrizsangi A, Shahrokh Shahraki S, Mokhtari A. Evaluation of the effects of A. jesdianum bacterial endophytes on some bacterial and fungal pathogens. Iran J Med Microbiol. 2021;15(3):281‒301.

Sayyar Khan M, Gao J, Munir I, Zhang M, Liu Y, Moe TS, et al. Characterization of endophytic fungi, Acremonium sp., from Lilium davidii and analysis of its antifungal and plant growth-promoting effects. Biomed Res Int. 2021;2021:9930210.

Atoum MF, Padma KRR, Don K. Paving new roads using Allium sativum as a repurposed drug and analyzing its antiviral action using artificial intelligence technology. Iran J Pharm Res. 2023;21(1):e131577. https://doi.org/10.5812/ijpr-131577.

Fritsch RM, Abbasi M. A Taxonomic review of Allium subg. Melanocrommyum in Iran. Edited by Reinhard M. Fritsch. IPK Gatersleben, Germany; 2013. p. 1‒218.

Amiri H. Chemical composition and antibacterial activity of the essential oil of A. jesdianum Boiss. & Buhse from Iran. J Med Plants. 2007;6(1):39‒44.

Askari Y. Composition of essential oil of Dorema aucheri Boiss. and A. jesdianum Boiss. medicinal plants. Int J Adv Biol Biomed Res. 2022;10(1):72‒83.

Fritsch RM. The Iranian species of Allium subg. Melnnocrommyum sect. Megaloprason (Alliaceae). Nord J Bot. 1996;16:9‒17.

Falahi E, Delshadian, Z, Ahmadvand H, Shokri Jokar S. Head space volatile constituents and antioxidant properties of five traditional Iranian wild edible plants grown in west of Iran. AIMS Agric Food. 2019;4(4):1034–53.

Ramak P, Karimian V, Siahmansour R. Comparison of the nutrients and chemical composition of A. jesdianum Boiss & Buhse in the habitats and field. Iranian Journal of Horticultural Science. 2020;51(1):19‒31.

Mimaki Y, Kuroda M, Fukasawa T, Sashida Y. Steroidal glycosides from the bulbs of A. jesdianum. J Nat Prod. 1999;62(1):194‒7.

Wazzan N. Phytochemical components of A. jesdianum flower as effective corrosion-resistant materials for Fe (1 1 0), Al (1 1 1), and Cu (1 1 1): DFT study. Arab J Chem. 2023;16(4):104625.

Khaksarian M, Gholami E, Alipour M, Sabooteh T, Asadi‐Samani M. Investigation of the effects of the essence and extract of A. jesdianum on the activity of COX‐1 and COX‐2 enzymes. International Journal of Advanced Biotechnology and Research. 2017;8(2):1095–101.

Khaksarian M, Meshkat AM, Farazifard R, Safarpour F. A study of chemistry and antinociceptive properties of medicinal plant A. jesdianum leaves and the probable role of opioidergic system. Yafteh. 2008;9(4):21–6.

Alaee M, Amri J, Karami H, Latifi SA, Salemi Z, Salehi M. A. jesdianum hydro alcoholic extract ameliorates diabetic nephropathy by suppressing connective tissue growth factor (CTGF) and receptor for advanced glycation endproducts (RAGE) gene expression in diabetic rats with streptozotocin. Horm Mol Biol Clin Invest. 2021;42(2):167–74.

Gholami A, Arabestani M, Ahmadi M. Evaluation of antibacterial activity of aqueous and methanol extracts of A. jesdianum plant on a number of pathogenic bacteria resistant to antibiotics. Pajouhan Scientific Journal. 2016;14(4):18‒26.

Ekrami M, Ekrami A, Hosseini MA, Emam-Djomeh Z. Characterization and optimization of Salep mucilage bionanocomposite films containing A. jesdianum Boiss. nanoliposomes for antibacterial food packaging utilization. Molecules. 2022;27:7032.

Naeini A, Yaraee R, Shokri H. Antifungal and immunomodulatory activity of A. jesdianum Boiss & Buhse extracts. J Herbmed Pharmacol. 2020;9(1):75‒80.

Shahrokh S, Vahedi G, Khosravi AR, Mahzounieh MR, Ebrahimi A, Sharifzadeh A, et al. In vitro antifungal activity of aqueous-ethanolic extract of A. jesdianum against fluconazole-susceptible and -resistant human vaginal Candida glabrata isolates. J HerbMed Pharmacol. 2017;6(4):165‒70.

Sarlak M, Nasiri Z, Madani M, Shahanipour K, Tognoni E, Shakib P. Investigating the effects of aqueous and alcoholic extracts of Allium hirtifolium and A. jesdianum on keratinase activity of Trichophyton mentagrophytes. Curr Drug Ther. 2022;17(1):39‒44.

Kalantari H, Shamsi ET, Samimi A, Kheradmand P, Shirani M, Zeidooni L. Histopathological and biomedical parameters determination in the protective effect of hydro alcoholic extract of A. jesdianum on hepatotoxicity induced by bromobenzene in mice. Iran J Pharm Sci. 2018;14(2):15‒24.

Kalantari H, Keshavarzi E, Kheradmand P, Goodarzian M, Zeidooni L. Protective effect hydroalcoholic extract A. jesdianum Boiss against CCl4-induced hepatotoxicity in male mice. J Rep Pharm Sci. 2018;7(3):389‒99.

Sohrabinezhad Z, Dastan D, Soleimani AS, Nili-Ahmadabadi A. A. jesdianum extract improve acetaminophen-induced hepatic failure through inhibition of oxidative/nitrosative stress. J Pharmacopunct. 2019;22(4):239‒47.

Jalili C, Golshani N, Bahrami Y, Roshankhah S, Salahshoor MR. Protective efficacy of A. jesdianum on liver parameters, inflammatory cytokines, oxidative injury and apoptotic changes in mercuric chloride-induced hepatotoxicity in rats. Eur J Anat. 2020;24(5):381‒389.

Kalantari H, Danesh Pajou M, Kheradmand P, Goodarzian M, Zeidooni L. Nephroprotective effect of hydroalcoholic extract A. jesdianum Boiss against carbon tetrachloride induced nephrotoxicity via stress oxidative in mice. Pharm Sci. 2018;24:89‒96. https://dx.doi.org/10.15171/PS.2018.14.

Alidadi H, Shirani M, Samimi A, Ashtari A, Salimi A, Khorsandi L. Anti-cancer activity of A. jesdianum extract loaded on microemulsions on colon cancer cells through suppression of autophagy and activation of necroptosis process. Jentashapir J Cell Mol Biol. 2022;13(1):e129206.

Dorosti N, Zarabi S, Ahmadi Sh, Rostami R, Rashidi Pour M. Anticancer activity evaluation of methanolic extract of A. jesdianum and Nectaroscordeum coelzi against HeLa and K562 cell lines. Yafteh. 2017;19(1):31–41.

Rashidi I, Hajalikhani P, Jalili C, Zhaleh M. The cytotoxic and migrastatic potentials of A. jesdianum hydroalcoholic extract on glioblastoma multiforme cell line model. World Cancer Res J. 2022;9:e2151.

Kamranfar F, Pourahmad Jaktaji R, Shirani K, Jamshidi A, Samiei F, Arjmand A, et al. Protective effect of A. jesdianum in an Alzheimer's disease induced rat mode. Preprint by Research Square; 2023.

Lorigooini Z, Ayatollahi SA, Amidi S, Kobarfard F. Evaluation of anti-platelet aggregation effect of some Allium species. Iran J Pharm Res. 2015;14(4):1225‒31.

Mousavi R, Fashi ZH, Jahromy MH, Rasooli R. Potential of the A. jesdianum extract in suppression of anxiety and depression in mice. Br Biomed Bull. 2017;5(2):302.

Vahdani R, Mehrabi S, Malekzadeh J, Sadeghi H, Jannesar R, Mehrabi F. Effects of hydrophilic extract of A. jesdianum on prevention and treatment of ethylene glycol induced renal stone in male Wistar rats. J Life Sci. 2013:10(12s):17‒21.

Ghorbanipour M, Sadeghi Dehkordi, Sazmand A, Daraei Garmakhany A, Sari A. Investigation of antioxidant characteristics and in vitro protoscolicidal effects of aqueous, alcoholic and hydroalcoholic extracts of A. jesdianum against protoscoleces of Echinococcus granulosus. Iran J Nutr Sci Food Technol. 2023;18(2):61‒73.

Naserabad SS, Zarei S, Rahimi J, Ghafouri Z, Mouludi-Saleh A, Banaee M, et al. Protective effects of A. jesdianum essential oil on Rainbow trout (Oncorhynchus mykiss) exposed to sub-lethal cypermethrin toxicity. Preprint by SSRN; 2023.

Angerhofer CK, Maes D, and Giacomoni PU. The use of natural compounds and botanicals in the development of anti-aging skin care products. In Dayan N, editor: Skin Aging Handbook: An Integrated Approach to Biochemistry and Product Development. Vol 10. William Andrew Inc.; 2008. p. 205–263.

Alemi M, Sabouni F, Sanjarian F, Haghbeen K, Ansari S. Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS PharmSciTech. 2013;14(1):160-7.

Ayanaw MA, Yesuf JS, Birru EM. Evaluation of analgesic and anti-inflammatory activities of methanolic leaf and root extracts of Gomphocarpus purpurascens A. Rich (Asclepiadaceae) in mice. J Exp Pharmacol. 2023;15:1–11.

Vardanyan RS. Hruby VJ: Synthesis of Essential Drugs. 1st ed. Amsterdam, Elsevier, 2006.

Published
2024-05-15
Section
Review Article