Physiological and Pharmacological Properties of the Swertia longifolia Boiss Plant and Its Compounds: A Mini Review
Abstract
Swertia longifolia, from the Gentianaceae family, grows in various regions of the world and is used in traditional and modern medicine to treat many diseases. The present study aimed to systematically review the physiological-pharmacological effects of this plant and its compounds. To conduct this scoping review, articles published in PubMed, ScienceDirect, Web of Science, Google Scholar, ProQest, Cochrane, SID, and Magiran databases were searched, using the keyword S. longifolia, on 18th March, 2023 to find relevant articles. S. longifolia contains effective compounds such as xanthones, iridoid glycosides, flavonoids, and triterpenoids, which have antioxidant, anti-cholinesterase, and anti-cytotoxic properties. Moreover, the extract of this plant and its compounds have anti-diabetic, hepatoprotective, and hypolipidemic properties and can inhibit the enzyme acetylcholinesterase. Given the effects of the extract and compounds of S. longifolia in the treatment of various diseases, it seems that clinical trials as well as more advanced studies should be conducted on each of the compounds of the plant which will be considered as new candidates for drug development in the future.References
Zarei A, Malekirad AA, Abdollahi M, Vaezi G, Changizi-Ashtiyani S. Swertia longifolia Boiss has beneficial effects on hepatic and renal functions in diabetic rats. Physiology and Pharmacology. 2017;21(2):163-71.
Hajimehdipoor H, Esmaeili S, Shekarchi M, Emrarian T, Naghibi F. Investigation of some biologic activities of Swertia longifolia Boiss. Research in pharmaceutical sciences. 2012;8(4):253-9.
Kshirsagar P, Jagtap U, Gaikwad N, Bapat V. Ethanopharmacology, phytochemistry and pharmacology of medicinally potent genus Swertia: An update. South African Journal of Botany. 2019;124:444-83.
Hussain W, Badshah L, Hussain F, Ali A. Floristic configuration and ecological characteristics of plants of Koh-e-Safaid range, northern Pakistani-afghan borders. Acta Ecologica Sinica. 2020;40(3):221-36.
Cao T-W, Geng C-A, Jiang F-Q, Ma Y-B, He K, Zhou N-J, et al. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity. Fitoterapia. 2013;89:175-82.
Jia Y, Xiong C. Assessing the biological activities of xanthone derivatives from Swertia macrosperma CB Clark. Natural product research. 2017;31(6):704-6.
Hajimehdipour H, Amanzadeh Y, Sadat Ebrahimi S, Mozaffarian V. Three tetraoxygenated xanthones from Swertia longifolia. Pharmaceutical biology. 2003;41(7):497-9.
Hajimehdipoor H, Dijoux-Franca M-G, Mariotte A-M, Amanzadeh Y, Sadat-Ebrahimi S-E, Ghazi-Khansari M. Two new xanthone diglycosides from Swertia longifolia Boiss. Natural Product Research. 2006;20(13):1251-7.
Saeidnia S, Ara L, Hajimehdipoor H, Read RW, Arshadi S, Nikan M. Chemical constituents of Swertia longifolia Boiss. with α-amylase inhibitory activity. Research in pharmaceutical sciences. 2016;11(1):23.
Sadeghi Z, Elmi S, Elmi A, Ghazi-Khansari M, Hajimehdipoor H, Amanzadeh Y, Sadat-Ebrahimi S-E. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. Journal of pharmacy and pharmacology. 2006;58(2):277-80.
Mészáros S, Höhn M. Species diversity and advancement of Swertia (Gentianaceae): ecological and morphological correlates. Acta Botanica Hungarica. 2002;44(3-4):317-34.
Huang Q, Wang Y, Wu H, Yuan M, Zheng C, Xu H. Xanthone glucosides: Isolation, bioactivity and synthesis. Molecules. 2021;26(18):5575.
Le Pogam P, Boustie J. Xanthones of lichen source: A 2016 update. Molecules. 2016;21(3):294.
Tovilovic-Kovacevic G, Zogovic N, Krstic-Milosevic D. Secondary metabolites from endangered Gentiana, Gentianella, Centaurium, and Swertia species (Gentianaceae): promising natural biotherapeutics. Biodiversity and Biomedicine: Elsevier; 2020. p. 335-84.
Shekarchi M, Hajimehdipoor H, Khanavi M, Adib N, Bozorgi M, Akbari-Adergani B. A validated method for analysis of Swerchirin in Swertia longifolia Boiss. by high performance liquid chromatography. Pharmacognosy Magazine. 2010;6(21):13.
Muhamad Fadzil NS, Sekar M, Gan SH, Bonam SR, Wu YS, Vaijanathappa J, et al. Chemistry, pharmacology and therapeutic potential of swertiamarin–A promising natural lead for new drug discovery and development. Drug Design, Development and Therapy. 2021:2721-46.
He Q-Y, Wang R, Sun X-C. Cytotoxicity of methanolic extract of Swertia petiolata against gastric cancer cell line SNU-5 is via induction of apoptosis. South African Journal of Botany. 2017;109:196-202.
HAJI MH, DIJOUX FM, Mariotte A, Amanzadeh Y, SADAT ES, GHAZI KM, MOZAFARIAN V. Phytochemical study of Swertia longifolia. 2008.
Mouffok S, Haba H, Lavaud C, Long C, Benkhaled M. Chemical constituents of Centaurea omphalotricha Coss. & Durieu ex Batt. & Trab. Rec Nat Prod. 2012;6(3):292-5.
Gohari AR, Saeidnia S, Shahverdi AR, Yassa N, Malmir M, Mollazade K, Naghinejad AR. Phytochemistry and antimicrobial compounds of Hymenocrater calycinus. Eur Asia J Bio Sci. 2009;3(9):64-8.
Chowdhury S, Islam M, Jung H, Choi J. In vitro antidiabetic potential of the fruits of Crataegus pinnatifida. Research in pharmaceutical sciences. 2014;9(1):11.
Nagmoti DM, Juvekar AR. In vitro inhibitory effects of Pithecellobium dulce (Roxb.) Benth. seeds on intestinal α-glucosidase and pancreatic α-amylase. Journal of Biochemical Technology. 2013;4(3):616-21.
Saraswathy A, Ariyanathan S. 1, 5, 8-Trihydroxy-3-methoxyxanthone from Swertia corymbosa (Griseb.) Wight ex. CB Clarke. International Journal of Pharmacy & Life Sciences. 2011;2(8).
Rathinavelusamy P, Mazumder PM, Sasmal D, Jayaprakash V. Evaluation of in silico, in vitro α-amylase inhibition potential and antidiabetic activity of Pterospermum acerifolium bark. Pharmaceutical Biology. 2014;52(2):199-207.
Sheng Z, Dai H, Pan S, Wang H, Hu Y, Ma W. Isolation and characterization of an α-glucosidase inhibitor from Musa spp.(Baxijiao) flowers. Molecules. 2014;19(7):10563-73.
Dumandan NG, Kagaoan ACT, Acda RD, Tumambing CR, Pham LJ. Extraction, Profiling, and Characterization of Phytosterols and Triterpenoids from Pili (Canarium ovatum Engl.) Pulp Oil Exhibiting Antioxidant and Antibacterial Properties. Biochemistry Research International. 2022;2022.
Negi JS, Singh P, Rawat B. Chemical constituents and biological importance of Swertia: a review. Current Research in Chemistry. 2010;3(1):1-15.
Patel D, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific journal of tropical biomedicine. 2012;2(4):320-30.
Kawanishi K, Ueda H, Moriyasu M. Aldose reductase inhibitors from the nature. Current Medicinal Chemistry. 2003;10(15):1353-74.
El Omari N, Jaouadi I, Lahyaoui M, Benali T, Taha D, Bakrim S, et al. Natural Sources, Pharmacological Properties, and Health Benefits of Daucosterol: Versatility of Actions. Applied Sciences. 2022;12(12):5779.
Luo Y-D, Chen J, Cao J, Wen X-D, Li P. Determination of sweroside in rat plasma and bile for oral bioavailability and hepatobiliary excretion. Chemical and Pharmaceutical Bulletin. 2009;57(1):79-83.
Jie L, Yaping L, Klaassen CD. The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. Journal of ethnopharmacology. 1994;42(3):183-91.
Subramanya SB, Venkataraman B, Meeran MFN, Goyal SN, Patil CR, Ojha S. Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury. International journal of molecular sciences. 2018;19(12):3776.
Ahamad J, Uthirapathy S, T Anwer E, S Mohammed Ameen M, Samad A. A Critical Review on Potential Pharmacological Activity and Pharmacokinetic Perspective of Swertiamarin. Research Journal of Phytochemistry. 2021;15(1):1-13.
Leong XY, Thanikachalam PV, Pandey M, Ramamurthy S. A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases. Biomedicine & Pharmacotherapy. 2016;84:1051-60.
Khanal S, Shakya N, Thapa K, Pant DR. Phytochemical investigation of crude methanol extracts of different species of Swertia from Nepal. BMC research notes. 2015;8(1):1-9.
UPendra Rao M SM, Chengaiah B, Jaganmohan Reddy MC. A review herbal medicines for diabetes mellitus. . IntJ PharmTech Res. 2010;2:1883.
Quan NV, Xuan TD, Tran H-D, Thuy NTD, Trang LT, Huong CT, et al. Antioxidant, α-amylase and α-glucosidase inhibitory activities and potential constituents of Canarium tramdenum bark. Molecules. 2019;24(3):605.
Vaidya H, Giri S, Jain M, Goyal R. Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin. Experimental & Clinical Cardiology. 2012;17(1):12.
Dhanavathy G. Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas. Journal of endocrinological investigation. 2015;38:669-84.
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