Antileishmanial Activity of Myrtle Methanolic Extract against Leishmaniamajor: an In Vitro Study

  • Hossein Mahmoudvand Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Hamed Salehi Lalehmarzi Bogomolets National Medical University, Kyiv, Ukraine
  • Shirzad Fallahi Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Maryam Moslehi Baharanchi Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Pardis Bayat Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Sareh Jahanbakhsh * Bam University of Medical Sciences, Bam, Iran
Keywords: Promastigote, Amastigote, Leishmania major, Medicinal plants, Cutaneous leishmaniasis, Myrtus communis


Background and Aim: In this study we assessed the in vitro antileishmanial activity of myrtle (Myrtus communis L.) methanolic extract against Leishmania major.Materials and Methods: The in vitro antileishmanial effects of myrtle methanolic extract against L. major promastigote and amastigotes were determined by colorimetric cell viability (MTT) assay and macrophage model, respectively. The IC50 values were also calculated by probit test in SPSS software.Results:The obtained results showed that myrtle extract was significantly inhibited promastigote growth of L. major based on a dose and time dependent manner. The measured IC50 values for myrtle methanolic extract and MA as control drug against promastigote forms of L. major were 23.6 µg/mL and 88.3 µg/mL, respectively. The obtained IC50 values were 13.8


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Original Article