The Antiviral Potential of Medicinal Plants in Treating Viral Infections

The Antiviral potentials of Medicinal Plants in treating viral infections

  • Amin Jaydari* Department of Pathobiology science, Faculty of veterinary Medicine, Lorestan University, Khorramabad, Iran
  • Elahe Sobhani Department of veterinary Medicine, Lorestan University, Khorramabad, Iran
  • Shahriyar Mehrabi DVSc Graduatedof Large Animal Internal Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Keywords: Influenza virus, Antiviral, Natural product, Medicinal plant


Recently, there has been remarkable progress in the field of antiviral herbal therapy owing to increasing concerns about the development of drug resistance and limited advances in the field of antiviral drug discovery. In almost all countries, medicinal plants have been widely used throughout history for the treatment of diseases and infections as traditional healing remedies due to their broad therapeutic spectrum and minimal or no side effects. As synthetic antiviral drugs are not available against most of the viral agents, hence all possible efforts have been focused on the search for new drugs and complementary alternative medicines from different herbal formulations. Despite their long history of use, the research and scientific evidence regarding the use of medicinal plants and natural products as prophylactics, therapeutics, and their health multiple beneficial applications have only gained momentum in the past few decades. Many scientific studies have been undertaken, which range from the separation of active substances to the comprehension of the therapeutic mechanisms of antiviral herbs, their potent applications in the neutralization of viral pathogens and clinical trials. Consequently, hundreds of herbs and plant metabolites have been screened, identified, and tested for their antiviral activities; fortunately, some have shown significant medicinal activity in the preventing or ameliorating of various viral diseases such as: Rabies, Influenza types A, B and C, Hepatitis B and C in both preclinical and clinical studies.


Khan T, Khan MA, Ullah N, Nadhman A. Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites. Biocatalysis and agricultural biotechnology. 2021;31:101890.

Hudson JB. The use of herbal extracts in the control of influenza. J Med Plants Res. 2009;3(13):1189-95.

Ohashi H, Watashi K, Saso W, Shionoya K, Iwanami S, Hirokawa T, et al. Multidrug treatment with nelfinavir and cepharanthine against COVID-19. BioRxiv. 2020:2020.04. 14.039925.

Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. nature. 2020;579(7798):270-3.

Rogosnitzky M, Danks R. Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions. Pharmacological reports. 2011;63(2):337-47.

Ben-Shabat S, Yarmolinsky L, Porat D, Dahan A. Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug delivery and translational research. 2020;10:354-67.

Kurokawa M, Shimizu T, Watanabe W, Shiraki K. Development of new antiviral agents from natural products. The Open Antimicrobial Agents Journal. 2010;2(1).

OKAMOTO M, ONO M, BABA M. Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. AIDS research and human retroviruses. 1998;14(14):1239-45.

Boukhatem MN, Setzer WN. Aromatic herbs, medicinal plant-derived essential oils, and phytochemical extracts as potential therapies for coronaviruses: future perspectives. Plants. 2020;9(6):800.

Zhang C-h, Wang Y-f, Liu X-j, Lu J-H, Qian C-w, Wan Z-y, et al. Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro. Chinese medical journal. 2005;118(06):493-6.

Aanouz I, Belhassan A, El-Khatabi K, Lakhlifi T, El-Ldrissi M, Bouachrine M. Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations. Journal of Biomolecular Structure and Dynamics. 2021;39(8):2971-9.

Abu-Jafar A, Huleihel M. Antiviral activity of Eucalyptus camaldulensis leaves ethanolic extract on herpes viruses infection. Int J Clin Virol. 2017;1:1-9.

Akram M, Tahir IM, Shah SMA, Mahmood Z, Altaf A, Ahmad K, et al. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytotherapy Research. 2018;32(5):811-22.

Alfajaro MM, Rho M-C, Kim H-J, Park J-G, Kim D-S, Hosmillo M, et al. Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract. Research in veterinary science. 2014;96(3):567-75.

Andersson S. General polyhedra, virus structure and mutation. Zeitschrift für Kristallographie. 2010;225(8):309-12.

Black IV WC, Bennett KE, Gorrochótegui-Escalante N, Barillas-Mury CV, Fernández-Salas I, de Lourdes Muñoz Ma, et al. Flavivirus susceptibility in Aedes aegypti. Archives of medical research. 2002;33(4):379-88.

Ali SI, Sheikh WM, Rather MA, Venkatesalu V, Muzamil Bashir S, Nabi SU. Medicinal plants: Treasure for antiviral drug discovery. Phytotherapy Research. 2021;35(7):3447-83.

Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, et al. Common nodes of virus–host interaction revealed through an integrated network analysis. Frontiers in immunology. 2019;10:2186.

Chiu Y-H, Chan Y-L, Tsai L-W, Li T-L, Wu C-J. Prevention of human enterovirus 71 infection by kappa carrageenan. Antiviral research. 2012;95(2):128-34.

Wang X, Jia W, Zhao A, Wang X. Anti‐influenza agents from plants and traditional Chinese medicine. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2006;20(5):335-41.

Rukachaisirikul V, Pailee P, Hiranrat A, Tuchinda P, Yoosook C, Kasisit J, et al. Anti-HIV-1 protostane triterpenes and digeranylbenzophenone from trunk bark and stems of Garcinia speciosa. Planta medica. 2003;69(12):1141-6.

Hussein G, Miyashiro H, Nakamura N, Hattori M, Kakiuchi N, Shimotohno K. Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2000;14(7):510-6.

Mao Y-M, Zeng M-D, Lu L-G, Wan M-B, Li C-Z, Chen C-W, et al. Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: a randomized, double blind, placebo-controlled, multicenter clinical study. World Journal of Gastroenterology: WJG. 2004;10(22):3269.

Dao TT, Dang TT, Nguyen PH, Kim E, Thuong PT, Oh WK. Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. Bioorganic & medicinal chemistry letters. 2012;22(11):3688-92.

Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clinical microbiology reviews. 2000;13(3):371-84.

Hardy ME, Hendricks JM, Paulson JM, Faunce NR. 18 β-glycyrrhetinic acid inhibits rotavirus replication in culture. Virology Journal. 2012;9(1):1-7.

Gandhi GR, Barreto PG, dos Santos Lima B, Quintans JdSS, de Souza Araujo AA, Narain N, et al. Medicinal plants and natural molecules with in vitro and in vivo activity against rotavirus: a systematic review. Phytomedicine. 2016;23(14):1830-42.

Henderson FW, Collier AM, Clyde Jr WA, Denny FW. Respiratory-syncytial-virus infections, reinfections and immunity: a prospective, longitudinal study in young children. New England Journal of Medicine. 1979;300(10):530-4.

Lu L-G, Zeng M-D, Mao Y-M, Fang J-Y, Song Y-L, Shen Z-H, et al. Inhibitory effect of oxymatrine on serum hepatitis B virus DNA in HBV transgenic mice. World Journal of Gastroenterology. 2004;10(8):1176.

Fuse T, Watanabe K, Kitazato K, Kobayashi N. Establishment of a new cell line inducibly expressing HIV-1 protease for performing safe and highly sensitive screening of HIV protease inhibitors. Microbes and infection. 2006;8(7):1783-9.

Van Rossum T, Vulto A, De Man R, Brouwer J, Schalm S. glycyrrhizin as a potential treatment for chronic hepatitis C. Alimentary pharmacology & therapeutics. 1998;12(3):199-205.

Patrick L. Hepatitis C: epidemiology and review of complementary/alternative medicine treatments. Alternative medicine review: a journal of clinical therapeutic. 1999;4(4):220-38.

Rajbhandari M, Wegner U, Jülich M, Schoepke T, Mentel R. Screening of Nepalese medicinal plants for antiviral activity. Journal of ethnopharmacology. 2001;74(3):251-5.

Nagai T, Miyaichi Y, Tomimori T, Suzuki Y, Yamada H. In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. Antiviral research. 1992;19(3):207-17.

Vijayan P, Raghu C, Ashok G, Dhanaraj S, Suresh B. Antiviral activity of medicinal plants of Nilgiris. Indian Journal of medical research. 2004;120:24-9.

Review Article