Effects of Herbal Medicines on Wound Repair via the Modulation of the Transforming Growth Factor Beta (TGFβ) and Basic Fibroblast Growth Factor (bFGF): A Mini-Review

  • Maryam Hormozi Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Mandana Beigi Boroujeni* Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Keywords: Wound healing, Transforming Growth Factor beta1, Medicinal plants


The transforming-growth factor β1 (TGFβ1) and basic fibroblast growth factor (bFGF) are two factors with significant roles in the wound healing process. There are two therapeutic approaches to wound repair consisting of beauty wise and strength wise. This study was conducted to review the roles of herbal medicines in the wound repair process focusing on the roles of TGFβ1 and bFGF according to approaches. Scientific databases, including Google Scholar, PubMed, Web of Science, and Scopus were searched to find review articles about using herbal medicines in wound repair. Further evidence confirmed the efficiency of aloe vera in comparison with other medicinal plants. That is, it could up-regulate both TGFβ1 and bFGF. Wound repair is a very complex process that requires interdisciplinary management. Targeting different parts of this complex mechanism may have different clinical results. Medicinal plants are not exceptions, and the use of these plants may have different outcomes. The management strategy of wounds depends on several factors.


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Review Article