Anti-Inflammatory and Antioxidant Potentials of Merremia hederacea (Burm.Fil) Leaves

Keywords: Merremia hederacea, Plant extracts, Phytochemicals, Antioxidants, Anti-inflammatory

Abstract

Background and Aim: This study aimed to identify the existence of phytochemical compounds and evaluate the in-vitro antioxidant and anti-inflammatory potentials of the leaves extract of Merremia hederacea which is commonly known as ivy woodrose. Materials and Methods: The antioxidant potency was measured using DPPH radical scavenging method and reducing power capacity followed by calculating phenol and flavonoid contents. To test the anti-inflammatory effect, the protein-denaturation method was applied. Results: Based on the DPPH scavenging activity, the IC50 value of the extract was determined to be 416.977. The amounts of phenolic content and flavonoids as well as the reducing power of this extract were found satisfactory. The extract remarkably hindered the denaturation of protein in the anti-inflammatory activity test with a maximum of 68.86% inhibition at 500 μg/mL concentration. Conclusion: The results indicate that M. hederacea leaves have favorable antioxidant and anti-inflammatory potencies; hence, this plant can be an effective source of new potent drugs

Author Biographies

Sanjida Sharmin*, International Islamic University Chittagong
Pharnacy Departmen,  Lecturer
Ranak Jahan Prova, International Islamic University Chittagong
Pharmacy Departmen,  student

References

Ekorm M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology. 2014;4:177.

Oyebode O, Kandula NB, Chilton PJ, Lilfard RJ. Use of traditional medicine in middle-income countries: a WHO-SAGE study. Health policy and planning. 2016;3(8):984-991.

Garland T, Barr AC & International Symposium on Poisonous . Toxic plants and other natural toxicants. USA: CAB International; 1998.

Ahsan RM, Islam MK, Haque EM & Mossaddik AM. In vitro antimicrobial screening and toxicity study of some different medicinal plants. Biology Published; 2009.

Rungsung W, Ratha KK, Dutta S, Dixit AK, Hazra J. Secondary metabolites of plants in drugs discovery. World Journal of Pharmaceutical Research. 2015;4(1):604-13.

Anwar H, Hussain G, Mustafa I. Antioxidants from natural sources: Antioxiidants in foods and its application. Faisalabad. Pakistan: Intech Open; 2018.

Sasidharan N. Kerala Forest Research Institute. Peechi. indian biodiversity portal.

Harborne A. Phytochemical methods a guide to modern techniques of plant analysis. Netherlands: springer science & business media: 1998.

Ullah HA, Zaman S, Juhara F, Akter L, Tareq SM, Masum EH, et al. Evaluation of antinociceptive, in-vivo & in-vitro anti-inflammatory activity of ethanolic extract of Curcuma zedoaria rhizome. BMC Complementary and Alternative Medicine. 2014;14:346.

Juvekar A, Sakat S, Wankhede S, Juvekar MN, Gambhire M. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Planta Medica. 2009;75(09).

Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M, Morelli I. Antioxidant principles from bauhinia t arapotensis. Natural Product Research. 2001;64(7):892-5.

Ferreira IC, Baptista P, Vilas-Boas M, Barros L. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity. Food Chemistry. 2007;100:1511-6.

Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American journal of Enology and Viticulture. 1965;16:144-58.

Waterhouse AL. Determination of total phenolics. Current protocols in food analytical chemistry. 2002;6(I1):11-8.

Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of Food Drug Analysis. 2002;10(3):178-82.

Pourmorad F, Hosseinimehr S, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. African Journal of Biotechnology. 2006;5 (11):1114-42.

Roy A. A review on the alkaloids an important therapeutic compounds from plants. International Journal of Plant Biotechnology. 2017;3(2):1-9.

Alves de Almeida AC, de-Feria FM, Dunder RJ, Manzo LPB, Souza-Brito ARM, Luiz-Ferreira A. Recent trends in Pharmacological Activities of Alkaloids in Animal Colitis: Potential use for inflammatory bowel disease. 2017. Evidence-based Complementary and Alternative Medicine. 2017;2017:1-24.

Koch R, Sun C, Minns A, F. Clark R. Cardiac Intensive Care: Overdose of cardiotoxic drugs. 3rd ed. Elsvier. 2019;351-66.

Bhuyan DJ, Basu A. Utilization of bioactive compounds from agricultural and food waste: Phenolic compounds: potential health benefits and toxicity. CRC Press;2017.

Dulce L. Ambriz-Perez, Leyva-Lopez N, Erick P, Guterriz-Grijalva. Heredia B. Phenolic compounds: Natural alternative in inflammation treatment.A review. Cogent Food and Agriculture. 2016:1:2.

Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview.Journal of Nutritional science. 2016;5:47.

Amarowiez R. Tannins: The new natural antioxidants. European Journal of Lipid Science and Technology. 2007;109(6).

Yucekultu AN. Application of saponins in foods and medicines. International Participation "Turkey National Nutrition and Healthy Life Day 2016 Congress. 2016.

Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. Journal of Agricultiral Food Chemistry. 1992;40(6):945-8.

Shon MY, Kim TH, Sung NJ. Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts. Food chemistry. 2003;82(4):593-7.

Published
2023-04-29
Section
Original Article