Medicinal Properties of Pomegranate

Esfandiar Hassani Moghadam *, Mahdi Shaaban, Asghar Sepahvand

Abstract


As an ancient fruit tree, pomegranate (Punica granatum L.) is one of the unique fruit trees cultivated in the Mediterranean region, particularly in Iran and in the Middle East. This tree is cultivated in majority of Iranian provinces. The mineral content and medicinal properties of pomegranate have been indicated in many previous research reports. The present review focuses on the medicinal properties of pomegranate fruit. Based on previous researches, we concluded that pomegranate has several medicinal uses in human diet. All parts of pomegranate tree have medicinal uses. Anti-cancer property is the main medicinal characteristic of this fruit tree. Pomegranate fruit has high amounts of phenolic compounds with a remarkable antioxidant activity. Moreover, one of the principal phenolic ingredients of pomegranate is ellagic acid which is characterized by high antioxidant activity. This review focuses on the recent researches on the medicinal properties of pomegranate fruit. The antioxidant activities and medicinal properties of pomegranate that are effective in the treatment of certain diseases were identified. However, we collected the best results of previous studies in carried out on this subject.



Keywords


Pomegranate, Medicinal properties, Ellagic acid, Antioxidant

Full Text:

PDF

References


S M. Outline of the beginnings of alchemy and its antecedents. Am J Chin Med. 1984;12:21-32.

MT JJ. Therapeutic applications of pomegranate (Punica granatum L.): A review. Altern Med Rev. 2008;13(123-144).

Lansky EP NR. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007;109:177-206.

Chavan AR. Physicochemical properties of pomegranate rind powder. Beverage and Food World. 1995;22(1):36-41.

Afaq ZM, Khan N, Dreher M, Mukhtar H. Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp Dermatol. 2009;18(6):553-61.

JS J. Therapeutic applications of pomegranate (Punica granatum L.): A review. Altern Med Rev. 2008;13(2):128-44.

Naovi KM, Vohora SB. Antibacterial, anti-fungal and anthelmintic investigations on Indian medicinal plants. Fitoterapia 1991;62:222-5.

Waheed S SN, Rahman A, Zaidi JH, Ahmad S. INAA for dietary assessment of essential and other trace elements in 14 fruits harvested and consumed in Pakistan. J Radioanal Nucl Chem. 2004;260:523-6.

Jafri AM, Javed K, Singh S. Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan induced diabetic rats. Journal of Ethnopharmacology. 2000;70:309-14.

Narzary D MK, Rana TS, Ranade SA Analysis of genetic diversity among wild pomegranates in Western Himalayas, using PCR methods. Sci Hortic. 2010;121:237-42.

Gill NS, Jain A, Arora R, Bali M. Antioxidant and anti-ulcerogenic activity of wild Punica granatum ethanolic seed extract. Research Journal of Medicinal plants. 2012;6(1):47-55.

Qu W ZP, Haile M. Extraction modeling and activities of antioxidants from Pomegranate marc. Journal of Food Engineering 2010;99:16-23.

Fadavi BM, Azizi MH, Bayat M. Physicochemical composition of ten pomegranate cultivars (Punica granatum L.) grown in Iran. Food Sci Technol Int. 2005;11:113-9.

Holland D, Hatib K, Bar-Yáakov I. Pomegranate: botany, horticulture, breeding, In: Horticultural Reviews. Publication W-B, editor. New Jersey; 2009.

Bhowmik D, Harish Gopinath B, Pragati Kumar S, Aravind G, Sampath Kumar KP. Medicinal Uses of Punica granatum and Its Health Benefits. Journal of Pharmacognosy and Phytochemistry. 2013;1(5):28-35.

Grossmann ME MN, Schuster T, Cleary MP Punicic acid is an -5 fatty acid capable of inhibiting breast cancer proliferation. Int J Oncol. 2010;36:421-6.

Pedriali FA, Santos P, Silva M, Severino D, Dilva M B. Antioxidant activity, cito- and phototoxicity of Pomegranate (Punica granatum L.) seed pulp extract”. Cienc Tecnol Aliment. 2010;30(4):1017-21.

Adhami KN, Mukhtar H. Cancer chemoprevention by pomegranate: Laboratory and clinical evidence. Nutr Cancer. 2009;61(6):811-6.

Ricci DGL, Bucchini A, Fraternale D. Antioxidant activity of Punica granatum fruits. Fitoterapia. 2006;77(4):310-2.

Rajan S. MS, Deepa V.M.,Sathya K.,Shajitha S.,Thirunalasundarii T Antioxidant potentials of Punica granatum fruit rind extracts. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(3):82-8.

Halilova H Y. Does climate change have an effect on proline accumulation in pomegranate (Punica granatum L.) fruits. Sci Res Essay. 2009;4:1543-6.

Hassani Moghadam E. Screening of six Iranain commercial pomegranate (Punica granatum L.) cultivars in response to drought stress based on some morphological, physiological and biochemical markers. Hamedan: BU-Ali Sina University; 2015.

Hassani Moghadam E, Esna-Ashari, M. and Rezainejad, A. Effect of Drought Stress on Some Physiological Characteristics in Six Commercial Iranian Pomegranate (Punica granatum L.) Cultivars. The Journal of Plant Production Technology. 2016;15(1):1-11.

Mena P GA, Collado-Gonzalez J, Ondono S, Garcia-Viguera C, Ferreres F. Sustained deficit irrigation affects the colour and phytochemical characteristics of pomegranate juice. J Sci Food Agric. 2013;93(8):1922-7.

Ghara’ati M. Translation and interpretation of the Holy Quran (summary of the ten-volume Tafsir Noor) (3rd ed.). Lessons from the Quran Cultural Center; 2016. p. 146.

Faghihi Rezaee M. Translation of the Holy Quran: Annotations on selected verses and a table of topics, for students Tehran: Islamic Republic of Iran Center for Publication of the Holy Quran; 2015.

Rezaee Esfahani MA. Interpretation of the Holy Quran (Mehr Javan: An interpretation of Tafsir Mehr). Qom: Nasim-e Hayat 2012.

Mohammadi Reyshahri M. Encyclopedia of medical hadiths Qom: Dar al-hadith 2004.

Fa’ali MT. he Razavi lifestyle: Health and nutrition. Mashhad:: Imam Reza International Cultural Institution 2015.

Sadegi N. JBOMR, Photovat M. Antioxidant activity of iranian Pomegranate (Punica granatum L.) seed extracts. J Agri Sci Tech. 2009;11:633-8.

Maria G. Miguel MANaMDA. Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review. Journal of Medicinal Plants Research. 2010;4(25):2836-47.

Ganguly S. Medicinal Utility of Pomegranate Fruit in Regular Human Diet: A Brief Review. International Journal of Forestry and Horticulture. 2017;3(1):7-18.

Satomi H UK, Ueno A, Hatano T, Okuda T, Noro T. Carbonic anhydrase inhibitors from the pericarps of Punica granatum L. Biol Pharm Bull. 1993;16:787-90.

Cambay Z BG, Tuzcu M, Bal R. Pomegranate (Punica granatum L.) flower improves learning and memory performances impaired by diabetes mellitus in rats. Acta Physiol Hung. 2011;98(4):209-20.

Tezcan F G-OuM, Diken T, Elik B, Erim FB. Antioxidant activity and total phenolic, organic acid and sugar content in commercial pomegranate juices. Food Chem. 2009;115(3):878-7.

Chaturvedula V. SPaIP. Bioactive Chemical Constituents from Pomegranate (Punica granatum) Juice, Seed and Peel-A Review. International Journal of Research in Chemistry and Environment 2011;1:1-18.

Kishore R K. SD, Parthasarathy P.R. Embryo protective effect of Pomegranate (Punica granatum L.) fruit extract in adriamycin-induced oxidative stress. Indian Journal of Biochemistry & Biophysics. 2009;43:106-11.

Davidson MH MK, Dicklin MR, Feinstein SB, Witchger MS, Bell M, McGuire DK, Provos JC, Liker H, Aviram M. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Ame J Cardiol. 2009;104(7):936-42.

Seeram N SRN, Heber D. Pomegranates: Ancient roots to modern medicine. CRC Press/Taylor & Francis, editor. Boca Raton2006.

Akpinar-Bayizit A. TOaLY-E. The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer, Cancer Prevention - From Mechanisms to Translational Benefits. Georgakilas DAG, editor; 2012.

Hassani Moghaddam E. Esna-Ashari, M. and Shaaban M. An Investigation of the Secondary Metabolites and Antioxidant Capacity of Some Commercial Iranian Pomegranate (Punica granatum L.) Cultivars under Drought Stress. Med J. 2018;3(1):14-25.

Schwartz E TR, Glazer I, Bar-Ya’Akov I, Wiesman Z, Tripler E, Bar-Ilan I, Fromm H, Borochov-Neori H, Holland D, Amir R Environmental conditions affect the color, taste, and antioxidant capacity of 11 pomegranate accessions’ fruits. J Agric Food Chem. 2009;57(9179-9209).

Stangeland T RS, Lye KA Total antioxidant in 35 Ugandan fruits and vegetables. Food Chem. 2009;113:85-91.

Kaur G JZ, Athar M ,Alam S. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food and Chemical Toxicology. 2006;44:982-93.

Gil M I. FA, Hess-Pierce B, Deirdre M.Adel A. K. Antioxidant activity of Pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000;48:4581-9.

Toi M BH, Ramachandran C, Melnik SJ, Imai A, Fife RS, Carr RE, Oikawa T, and Lansky EP. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. . Angiogenesis. 2003;6(2):121-8.

Cravatto G BL, Genzini L, Garella D Phytotherapeutics: An evaluation of the potential of 1000 plants. J Clin Pharm Ther. 2010;35:11-48.

Syed DN AF, Mukhtar H. Pomegranate derived products for cancer chemoprevention. Sem Cancer Biol. 2007;17:377-85.

Amin ARMR KO, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol. 2009;27:2712-25.




DOI: https://doi.org/10.22087/herb%20med%20j.v4i3.759

Refbacks

  • There are currently no refbacks.


This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

                               

This work is licensed under a Creative Commons license (CC-BY).  However, the license permits any user to read, copy, redistribute and and make derivative the material in any medium or format for any purpose, even commercially.


 

Lorestan University of Medical Sciences, Khorramabad, Iran.

ISSN: 2538-2144