Authors
1
School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India
2
School of Pharmaceutical Sciences Apeejay Stya University, Gurugram, Haryana, India
3
Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India
4
Department of nursing, Patna Medical College Hospital, Patna, Bihar, India Amity College of Nursing, Amity University, Gurugram, Haryana, India
10.22087/hmj.v9i2
Abstract
Quinolone antibacterial molecules are the most impactful types of anti-infective, active pharmaceutical
ingredients in our never-ending battle against pathogens. Additionally, in contrast to many anti-infective classes,
the discoverers published a startlingly small amount of information regarding the origin of the class or the
justification for this significant group's first FDA-approved agent, nalidixic acid. With an emphasis on the
Quantitative Structure-Activity Relationship (QSAR), chemistry, development, adverse effect, and future aspects
of this class of antibiotics, this article discusses the discovery, total synthetic methods, pharmacology, clinical
applications, and further lead to the new pipeline that produced various large selling and widely used antibiotics.
Keywords: Nalidixic Acid, Synthesis, Development, Quinolones, Fluoroquinolones
