Background and Aim: Many studies have been conducted worldwide to control blood pressure through herbal medicines. The present study was conducted to investigate ginger's role in the treatment of hypertension. Materials and Methods: Fifty-four male Wistar rats weighing about 200 to 250 grams were randomly divided into 6 groups (3 groups of ten, and 3 groups of eight rats) for in vivo investigation. The left renal artery was blocked using a non-allergenic stainless-steel clamp to create hypertension. Then, the hydroalcoholic extract of ginger was prepared using distilled water in three doses of 100, 200, and 300 mg/kg. Oral gavage administration was used for the rats daily for 42 days using the hydroalcoholic extract of ginger. Pulmonary blood pressure was assessed using a cuff sphygmomanometer. Electrocardiogram (EKG or ECG) and echocardiogram (echo) tests were also performed after the end of the gavage on the 42nd day. Moreover, the amount of nitric oxide (NO) in serum samples was measured using the Griess reagent system. After categorizing raw data in Excel, they were analyzed using analysis of variance (ANOVA) by SPSS software. Results: In this study, it was observed that ginger could notably decrease blood pressure. This decrease in blood pressure is due to the diuretic effect of the ginger's extract. Consequently, the use of ginger decreases the amount of NO. Furthermore, these data revealed that ginger had no toxic effect on the heart, and using this plant in hypertensive heart disease patients is safe. Conclusion: Considering the positive effects of ginger in decreasing blood pressure and its non-toxicity for the heart, it is recommended to conduct further specialized studies and clinical trials in this regard.