Effects of the Topical Application of Lavandula Officinalis L. Essential Oil on Reducing the Severity of Eczema Symptoms: A Randomized Clinical Trial

Rashidipour, Marzieh; Zarei Venovel, Mojgan; Alekasir, Asma; Ebrahimzadeh, Farzad; Hadavand, Samaneh; Matoorian Pour, Hossein; Ahmad Pour, Forozan

doi:10.22087/hmj.v8i2.936

Effects of the Topical Application of Lavandula Officinalis L. Essential Oil on Reducing the Severity of Eczema Symptoms: A Randomized Clinical Trial

Authors

Marzieh Rashidipour ¹

Mojgan Zarei Venovel ²

Asma Alekasir ¹

Farzad Ebrahimzadeh ¹

Samaneh Hadavand ¹

Hossein Matoorian Pour ³

Forozan Ahmad Pour ¹

¹ Razi Herbal Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

² Student Research Committee, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran

³ Department of Dermatology, Lorestan University of Medical Sciences, Khorram Abad, Iran

10.22087/hmj.v8i2.936

Abstract

Background and Aim: Lavandula Officinalis L. essential oil (L.O) has different effects such as anti-inflammatory and soothing effects on skin diseases. The aim of this study was to examine the the effect of L.O on the severity of eczema. Materials and Methods: This research was conducted as an open-label, randomized clinical trial. The patients who were enrolled to participate in the present study were randomly divided into five groups. In groups A, B, and C, 15 patients in each group received lavender essential oil cream at a dose of 3%, 5%, and 8%, respectively. In groups D and E, 15 patients in each group received 1% topical hydrocortisone and cream base, respectively. All the patients used the cream twice a day for 14 days. Baseline characteristics of the enrolled subjects and illness severity were recorded at the baseline and during the 7th as well as 14th days. Results: Generalized estimating equations (GEE) method showed that the interaction of the experimental group and time factor on the severity of eczema was significant (P = 0.011). Moreover, the relative chance of higher eczema severity in experimental groups was different, and it was a function of time. The relative chance of any increase in the severity of eczema in groups A, B, C compared with group E on the 7th day of treatment was reduced by about 9.7%, 34.7%, and 73.9%, respectivelyt; while on the 14th day of treatment, it decreased by about 79.2%, 82.4%, and 97.7%, respectively. The lavender oil significantly reduced the severity of eczema at the 7th and end of the 14th day (P ≤ 0.01). Conclusion: Lavender has dose-dependently beneficial effects on the treatment of eczema.

Keywords

Eczema

Lavender essential oil

Skin cream