Herbal Medicines Journal
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Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model

Document Type : Original Article

Authors

Raheleh Assaei 1
Naser Pajouhi 2

1 1 Department of Physiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran 2 Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

2 Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

10.22087/herb%20med%20j.v3i3.743
Abstract
Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models.Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays.Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion.Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders.

Keywords

Anti-spasmodic
Diarrhea
Satureja khuzestanica
Intestinal transit
Intestinal secretion
Rats
Herbal Medicines Journal
Volume 3, Issue 3
Spring 2018
Pages 101-108

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