Document Type : Original Article
Authors
1
Nutritional Health Research Center, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
2
Nutritional Health Research Center, Health and Nutritional Department, Lorestan University of Medical Sciences, Khorramabad, Iran
3
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
4
Students Research Committee, Nutritional Health Research Center, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract
ABSTRACT
Background: Depression, anxiety, and stress are common among individuals with type 2 diabetes. This study aimed to investigate the effects of curcumin–piperine supplementation on stress, depression, and anxiety in patients with type 2 diabetes.
Methods: In this randomized, double-blind, placebo-controlled trial, 64 patients with type 2 diabetes who met the inclusion criteria were randomly assigned to receive either one capsule of 500 mg curcumin–piperine supplement or one placebo daily for 12 weeks. Anthropometric indices as well as scores for depression, stress, and anxiety were measured at baseline and after the intervention.
Results: All 64 patients completed the study. Compared to the placebo group, the curcumin–piperine group showed a significant reduction in stress and anxiety scores (P = 0.005 and P = 0.038, respectively). No significant differences were observed in depression scores (P = 0.163), body mass index (BMI, kg/m²), waist circumference (WC, cm), or body weight (kg) between the two groups (BMI: 29.97 ± 4.54 vs. 28.95 ± 3.85; WC: 103.56 ± 13.71 vs. 96.12 ± 13.71; weight: 83.64 ± 14.30 vs. 74.53 ± 11.82, respectively).
Conclusion: Daily curcumin–piperine supplementation significantly reduced stress and anxiety levels in patients with type 2 diabetes, though no significant effects were observed on depression or anthropometric measures.
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