Herbal Medicines Journal
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Quercetin as a Potential Therapeutic Agent for Meningioma: A Mini-Review of Mechanisms and Future Perspectives

Document Type : Review Articles

Author

Sayyid Ali Hosseini

Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

10.22087/hmj.2026.565121.1031
Abstract
Meningioma is the most common primary intracranial tumor, affecting a significant number of people worldwide. Therefore, discovering effective strategies for its prevention and treatment is vital to minimizing its impact. Quercetin is a flavonoid found in fruits, vegetables, leaves, seeds, and grains. Studies have shown its effectiveness in treating various types of neurological cancer. This review summarizes the mechanisms of action and therapeutic effects of quercetin in the treatment of meningioma. Google Scholar, PubMed, Scopus, and Web of Science were searched to find relevant articles published in these databases from 1993 to 2025. According to our findings, quercetin, via microRNA-mediated mechanisms and interactions with type II estrogen binding sites, induces cell death, inhibits proliferation, and reduces cell growth in cancer cells. Thus, based on limited in vitro evidence, quercetin may represent a promising candidate for further investigation as a therapeutic approach for meningioma. However, the encouraging preclinical data should be evaluated in clinical settings through additional studies, with appropriate methods.

Keywords

Meningioma
Quercetin
Anticancer Effects
Signaling pathways
Mechanisms

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