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The Expanding Role of Medicinal Plants in the Management of Viral Infections

Editorial

Author

Department of Pharmacology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

10.22087/hmj.2026.245505
Abstract
Viral infections remain a major global health challenge due to rapid viral mutations, drug resistance, and limitations in current antiviral therapies. In recent years, medicinal plants have gained increasing attention as potential complementary resources in the management of viral diseases. Many plant-derived bioactive compounds, including flavonoids, alkaloids, terpenoids, polyphenols, and essential oils, exhibit antiviral, anti-inflammatory, antioxidant, and immunomodulatory activities. These compounds can interfere with various stages of the viral life cycle, such as viral entry, replication, and protein synthesis, while also modulating host immune responses. Traditional medical systems have long utilized plant-based remedies, and modern pharmacological research continues to validate many of these therapeutic effects. The COVID‑19 pandemic further stimulated global interest in phytomedicine and highlighted the need to explore natural antiviral agents. However, medicinal plants should be considered complementary rather than substitutes for evidence-based antiviral treatments and vaccination. Future progress requires rigorous scientific evaluation, including standardization of herbal extracts, identification of active compounds, toxicity assessment, pharmacokinetic analysis, and well‑designed clinical trials. Sustainable harvesting and biodiversity conservation are also essential to ensure long‑term availability of valuable medicinal species. Overall, medicinal plants represent a promising and integrative approach for enhancing antiviral strategies and improving global health outcomes.

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